leukocytosis and diabetic ketoacidosis

[MudPhud20XX]

FA says "leukocytosis" is seen in diabetic ketoacidosis, can anyone explain this please?
Is it b/c DKA can be triggered by infection?

Also, will the serum TG be decreased in DKA due to its breakdown to free fatty acid? But then why doesn't gluconeogenesis kick in to generate energy in DKA?

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[Phloston]

FA says "leukocytosis" is seen in diabetic ketoacidosis, can anyone explain this please?
Is it b/c DKA can be triggered by infection?

Also, will the serum TG be decreased in DKA due to its breakdown to free fatty acid? But then why doesn't gluconeogenesis kick in to generate energy in DKA?

My reasoning is going to be shorter than you're probably looking for, but in DKA I'd assume it's a 'stress' situation where cortisol and catecholamine receptor binding increase. And we know for instance that cortisol causes demargination of leukocytes, notably neutrophils.

And if you're breaking down fatty acids you get mostly acetyl-CoA, which in the catabolic state goes to ketones. Propionyl-CoA in odd-chain FA breakdown can go to the TCA cycle and then back up to glucose, but that's fractional.

 

[tasar1898]

Also in DKA oxaloacetate gets depleted in the liver so all FFA's delivered to it get shunted to ketone bodies --> ketosis

 

[Transposony]

But then why doesn't gluconeogenesis kick in to generate energy in DKA?

Gluconeogenesis does kick in and contributes to hyperglycemia but without much insulin around it cant generate ATPs.
Inhibition of gluconeogenesis is one of the mechanism of action of metformin.