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After analyzing neuropathological changes in patients that had a history of Alzheimer's disease and a lifetime history of major depression, researchers found out that there are more plaque and tangle deposits in the hippocampus of postmortem samples. Researchers have suggested that such patients will exhibit a more rapid cognitive decline than those without a history of depression.
While there is still more room for investigation (such as neuroimaging data), these results imply possible new clinical approaches in the treatment of Alzheimer's. Any comments?
Archives of General Psychiatry, February 2006
Rapp, Michael A. MD. PhD., et al. " Increased Hippocampal Plaques and Tangles in Patients With Alzheimer Disease With a Lifetime History of Major Depression," pp 161-167;
While there is still more room for investigation (such as neuroimaging data), these results imply possible new clinical approaches in the treatment of Alzheimer's. Any comments?
Archives of General Psychiatry, February 2006
Rapp, Michael A. MD. PhD., et al. " Increased Hippocampal Plaques and Tangles in Patients With Alzheimer Disease With a Lifetime History of Major Depression," pp 161-167;
