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- Feb 14, 2016
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Do low levels of albumin call for a lower loading dose or maintenance dose of a drug? One way I was thinking about it is that a lower loading dose would be required because low albumin levels may indicate a higher volume of distribution so more drug can enter the body (ie tissues) with a lower dose. However, I also learned the equation, LD= Css x Vd, which shows loading dose and volume of distribution having a directly proportional relationship, which would mean increase in Vd leads to increase in LD. This contradicts the statement I just mentioned about needing a lower dose. I would appreciate it if anybody could point out any mistakes in my understanding.