What is the rationale behind tapering of immunosuppressant dose a while after transplant?

This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.

Polycherry

Full Member
7+ Year Member
Joined
Nov 21, 2014
Messages
45
Reaction score
8
MMF, Cyclosporine, Prednisolone, Tacrolimus the dose of whatever immunosuppressant used is reduced in around 6 months - 1 year after the transplant.

What is the rationale behind this?

Wouldn't any allograft, howsoever old, still remain foreign? Does the body learn to consider the graft self? Or is the response still there but the destruction is reduced?

Why should a new graft elicit more response than an old one?
 
Top