loop diuretics and hypertonicity of medulla

[MudPhud20XX]

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So FA says loop diuretics abolish hypertonicity of medulla and prevent concentration of urine. Can anyone explain the mech? Many thanks in advance.

 

[seminoma]

Block NKCC reabsorption = no solutes in the medulla. No solutes in the medulla = no gradient for reabsorption of water.