Step I MAOI vs COMT

Started by DrTacoElf
Get help with your application

Use all the free resources available to you from SDN: articles, guides, expert advising, forums discussions, and school research.

Browse articles Compare schools My application plan Read Interview Feedback
Practice for interviews Ask an Advisor
DrTacoElf

DrTacoElf

Full Member
Verified Member
Dentist
20+ Year Member
So if someone is on MAOI and eats food high in tyramine they get hypertension. Why does COMT not take care of this excess catecholamine load. Does anyone have a good explanation for the difference between the two enzymes?

Thanks!
 
Sort by date Sort by votes
My best guess is that the methylated catecholamines still have some activity, but I can't tell you for sure off the top of my head. If I recall, tyramine is also degraded by MAO, so it'll continue to trigger catecholamine release, giving you a build-up of vasoactive stuff.
 
Upvote 0 Downvote
You must log in or register to reply here.