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Effective May 1st, 2025:
NAPLEX Exam Content will be updated with the following changes:
2025 - NAPLEX Content Outline
Content Doman Weights
1) Foundational Knowledge for Pharmacy Practice - 25% (50 Questions)
2) Medication Use Process (Prescribing, Transcribing/Documentation, Dispensing, Administering, Monitoring) - 25% (50 Questions)
3) Person-Centered Assessment & Treatment Planning - 40% (80 Questions)
4) Person-Centered Assessment & Treatment Planning - 5% (10 Questions)
5) Pharmacy Management & Leadership - 5% (10 Questions)
DOMAIN 1. FOUNDATIONAL KNOWLEDGE FOR PHARMACY PRACTICE
A. Pharmaceutical science principles and concepts
1. Pharmacology
2. Pharmacokinetics, pharmacodynamics, or pharmacogenomics
3. Pharmaceutics
B. Pharmaceutical compounding
1. Nonsterile preparations
2. Sterile preparations
C. Pharmaceutical calculations
1. Patient parameters or laboratory measures
2. Quantities of drugs to be dispensed or administered
3. Rates of administration
4. Dose conversions
5. Drug concentrations, ratio strengths, osmolarity, or osmolality
6. Quantities of drugs or ingredients to be compounded
7. Nutritional needs and the content of nutrient sources
8. Biostatistical, epidemiological, or pharmacoeconomic measures
9. Pharmacokinetic parameters
D. Drug development processes (eg, clinical trial phases, emergency use authorizations)
E. Research design principles and biostatistics (eg, blinding, randomization, biases, statistical tests and outcomes, ethics)
F. Retrieval, assessment, and interpretation of primary, secondary, and tertiary resources
DOMAIN 2. M.U.P. (PRESCRIBING, TRANSCRIBING/DOCUMENTING, DISPENSING, ADMINISTERING, MONITORING)
A. Prescriptions and medication order interpretation
1. Drug names and therapeutic classes
2. Indications, usage, and dosing regimens
3. Available dosage forms
4. Prescription regulations (eg, boxed warnings, risk evaluation and mitigation strategies)
5. Safety and effectiveness (eg, laboratory parameters, vital signs)B. Therapeutic substitutions (eg, formulary restrictions, therapeutic alternatives, shortages, biosimilars)
C. Immunization services and documentation
1. Indications and scheduling
2. Contraindications and precautions
3. Storage and handling
4. Administration (eg, techniques, preparation, routes)
5. Adverse reactions
D. Medication handling, storage, stability, and disposal (eg, hazardous and nonhazardous drugs, controlled substances, parenteral medications, sharps handling, temperature control)
3. PERSON-CENTERED ASSESSMENT AND TREATMENT PLANNING
A. Medication history, allergy history, and reconciliation
B. Health histories, screenings, and assessments
C. Patient health conditions, including special populations and medication related factors
1. Signs, symptoms, and findings of medical conditions, etiology of diseases, or pathophysiology
2. Appropriateness of therapy (eg, meds, immunizations, nondrug therapy, dosing, CIs, warnings, evidence based decision making)
3. Interactions (eg, drug-drug, drug-condition, drug-food, drug allergy, drug-laboratory)
4. Errors and omissions (eg, dosing, duplication, additional therapy needed, unnecessary therapy)
5. Adverse drug reactions
6. Toxicologic exposures and overdoses
7. Adherence
D. Therapeutic monitoring, plan development, evaluation, and modifications
1. Therapeutic goals, clinical endpoints, and follow-up
2. Safety
3. Effectiveness
E. Patient education
1. Lifestyle modifications and health maintenance
2. Medication use, storage, and disposal3. Disease state management
F. Over-the-counter medications and dietary supplements
G. Devices to administer medications and self-monitoring tests
DOMAIN 4. PROFESSIONAL PRACTICE
A. Adverse drug event reporting and medication error reporting (eg, MedWatch, VAERS)
B. Public health initiatives and risk-prevention programs (eg, tobacco and nicotine cessation, antimicrobial stewardship, health screenings, opioid stewardship)
C. Social determinants and drivers of health
D. Ethical considerations (eg, informed consent, ethical principles, professional conduct and responsibility, patient confidentiality)
DOMAIN 5. PHARMACY MANAGEMENT AND LEADERSHIP
A. Pharmacy operations (eg, operational planning, risk management, regulations and regulatory bodies, technology applications and informatics, error-prevention strategies, medication safety)
B. Inventory and supply management (eg, drug recalls, drug shortages)
C. Quality improvement activities (eg, medication use evaluation, root-cause analysis, continuous quality improvement)
D. Mentorship and preceptorship (eg, providing and receiving feedback, delegation of work activities, preceptor roles)
NAPLEX Exam Content will be updated with the following changes:
2025 - NAPLEX Content Outline
Content Doman Weights
1) Foundational Knowledge for Pharmacy Practice - 25% (50 Questions)
2) Medication Use Process (Prescribing, Transcribing/Documentation, Dispensing, Administering, Monitoring) - 25% (50 Questions)
3) Person-Centered Assessment & Treatment Planning - 40% (80 Questions)
4) Person-Centered Assessment & Treatment Planning - 5% (10 Questions)
5) Pharmacy Management & Leadership - 5% (10 Questions)
DOMAIN 1. FOUNDATIONAL KNOWLEDGE FOR PHARMACY PRACTICE
A. Pharmaceutical science principles and concepts
1. Pharmacology
2. Pharmacokinetics, pharmacodynamics, or pharmacogenomics
3. Pharmaceutics
B. Pharmaceutical compounding
1. Nonsterile preparations
2. Sterile preparations
C. Pharmaceutical calculations
1. Patient parameters or laboratory measures
2. Quantities of drugs to be dispensed or administered
3. Rates of administration
4. Dose conversions
5. Drug concentrations, ratio strengths, osmolarity, or osmolality
6. Quantities of drugs or ingredients to be compounded
7. Nutritional needs and the content of nutrient sources
8. Biostatistical, epidemiological, or pharmacoeconomic measures
9. Pharmacokinetic parameters
D. Drug development processes (eg, clinical trial phases, emergency use authorizations)
E. Research design principles and biostatistics (eg, blinding, randomization, biases, statistical tests and outcomes, ethics)
F. Retrieval, assessment, and interpretation of primary, secondary, and tertiary resources
DOMAIN 2. M.U.P. (PRESCRIBING, TRANSCRIBING/DOCUMENTING, DISPENSING, ADMINISTERING, MONITORING)
A. Prescriptions and medication order interpretation
1. Drug names and therapeutic classes
2. Indications, usage, and dosing regimens
3. Available dosage forms
4. Prescription regulations (eg, boxed warnings, risk evaluation and mitigation strategies)
5. Safety and effectiveness (eg, laboratory parameters, vital signs)B. Therapeutic substitutions (eg, formulary restrictions, therapeutic alternatives, shortages, biosimilars)
C. Immunization services and documentation
1. Indications and scheduling
2. Contraindications and precautions
3. Storage and handling
4. Administration (eg, techniques, preparation, routes)
5. Adverse reactions
D. Medication handling, storage, stability, and disposal (eg, hazardous and nonhazardous drugs, controlled substances, parenteral medications, sharps handling, temperature control)
3. PERSON-CENTERED ASSESSMENT AND TREATMENT PLANNING
A. Medication history, allergy history, and reconciliation
B. Health histories, screenings, and assessments
C. Patient health conditions, including special populations and medication related factors
1. Signs, symptoms, and findings of medical conditions, etiology of diseases, or pathophysiology
2. Appropriateness of therapy (eg, meds, immunizations, nondrug therapy, dosing, CIs, warnings, evidence based decision making)
3. Interactions (eg, drug-drug, drug-condition, drug-food, drug allergy, drug-laboratory)
4. Errors and omissions (eg, dosing, duplication, additional therapy needed, unnecessary therapy)
5. Adverse drug reactions
6. Toxicologic exposures and overdoses
7. Adherence
D. Therapeutic monitoring, plan development, evaluation, and modifications
1. Therapeutic goals, clinical endpoints, and follow-up
2. Safety
3. Effectiveness
E. Patient education
1. Lifestyle modifications and health maintenance
2. Medication use, storage, and disposal3. Disease state management
F. Over-the-counter medications and dietary supplements
G. Devices to administer medications and self-monitoring tests
DOMAIN 4. PROFESSIONAL PRACTICE
A. Adverse drug event reporting and medication error reporting (eg, MedWatch, VAERS)
B. Public health initiatives and risk-prevention programs (eg, tobacco and nicotine cessation, antimicrobial stewardship, health screenings, opioid stewardship)
C. Social determinants and drivers of health
D. Ethical considerations (eg, informed consent, ethical principles, professional conduct and responsibility, patient confidentiality)
DOMAIN 5. PHARMACY MANAGEMENT AND LEADERSHIP
A. Pharmacy operations (eg, operational planning, risk management, regulations and regulatory bodies, technology applications and informatics, error-prevention strategies, medication safety)
B. Inventory and supply management (eg, drug recalls, drug shortages)
C. Quality improvement activities (eg, medication use evaluation, root-cause analysis, continuous quality improvement)
D. Mentorship and preceptorship (eg, providing and receiving feedback, delegation of work activities, preceptor roles)
