Mechanism for Loop Diuretics

[MudPhud20XX]

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So I get the idea that the loop diuretics will block Na+/K+/2Cl- transporter thus basically decrease all the cations reabsorption, but how does this lead to increased diuresis? I mean isn't thick ascending loop where loop diuretics work impermeable to water? Can anyone help me out?
Thank you.

 

[bulldogmed]

loop diuretics work by not allowing reaborption of the ions in the tubule. This promotes diuresis b/c the osmolality of the tubule doesn't decrease as it usually does. Though the TAL is impermeable to water, further down the tubule, specifically in the DCT and the CD, it is, so failure to dilute the urine in the TAL means that water can't flow down it's concentration gradient later on. You have to take the kidney as a whole to understand how diuretics work in specific areas. Make sense?

 

[MudPhud20XX]

loop diuretics work by not allowing reaborption of the ions in the tubule. This promotes diuresis b/c the osmolality of the tubule doesn't decrease as it usually does. Though the TAL is impermeable to water, further down the tubule, specifically in the DCT and the CD, it is, so failure to dilute the urine in the TAL means that water can't flow down it's concentration gradient later on. You have to take the kidney as a whole to understand how diuretics work in specific areas. Make sense?

Yup! Got it man! Thanks!