Unless you get scholarships or have rich parents, the rule of thumb I use is (at least in Florida)...
In-State Public School: $45k/year
In-State Private School: $55k/year
Out-State School: $65k+/year
That's allopathic schools. Osteopathic schools tend to cost more, or carribean allopathic schools cost more too.
Each school is of course different, and unless you again have scholarships or rich parents, I'd expect to borrow the entire maximum budget put out by the school (add a few thousand to those published in books). The amount goes up by a thousand or two each year.
So in my case at a public school in-state, $45k times 4 years is $180k (minus a minuscule $1k scholarship, won't even factor that in). By the time you factor in interest paid over time, It'll cost around double that or $360k. Basically another mortgage on top of whatever mortgage you get for a house after residency.