Medical Degree/PhD or research fellowship?

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Hi guys,

Just a quick question and I hate to sound like a newbie here. I've been looking on the internet and on the forums about possible joint degree options. There was a thread in pre-osteo about DO/PhD and MSTP in which the whole fellowship vs. PhD came up and I was wondering if anyone could enlighten me on the differences. I have read a few of the threads but alot of information was specific to particular people and I'm looking for general information for maybe a pre-med student who is trying to determine the best path for them.

I realize that the fellowship doesn't give PhD but maybe someone has some insight on the directional differences of each program including a residency with clinical investigator pathways.

I'm looking from two perspectives of basic science research and clinical research.

I appreciate any insight you might have! Thanks!
 
I am a MD/PhD student in my last year of medical school. The best single piece of advice I can give is to get exposure to both clinical medicine and basic science research.

If you love basic research and know that is what you want to do, DO NOT GO TO MEDICAL SCHOOL, just get a PhD. After the PhD, you will need to do a postdoctoral fellowship (2-3 years) in order to get a job either in academics (university or medical school) or in industry.

If you like medicine, you have several options. If you are positive you want to do basic research and clinical medicine, I wiould apply for a combined MD/PhD program (AKA MSTP - Medical Scientist Training Program) when you apply for medical school. If accepted, they will pay your tuition plus a living stipend thoughout your training. At most schools, you complete your first 2 years of medical school, take off to complete your PhD training (3-4 years), then return to finish the last 2 years (clinical) of medical school.

However, you can always do basic research with just an MD, but you will need some formal education to learn how to write grants, design experiments, etc. This can be accomplished by doing a residency designed for Physician-Scientists where a post-doctoral research fellowship is combined with residency training.

My advice is to shadow a clinician and see if you like medicine. Equally important, if you have time, is to find a good basic science lab where you can get some experience. Don't jump into the first lab you caome to. Talk with a few faculty members and find the person and lab that you feel the most comfortable with - this is crucial, because it can make or break your experience.
 
Hello mushy, hope all is well.

Just a quick question and I hate to sound like a newbie here.

We're all newbies. Don't worry about it.

I've been looking on the internet and on the forums about possible joint degree options. There was a thread in pre-osteo about DO/PhD and MSTP in which the whole fellowship vs. PhD came up and I was wondering if anyone could enlighten me on the differences.

This is always a difficult question that gets much debate on all levels. Which is the best way to train somebody to be a physician-scientist? Should we invest in them on the front end by giving them a PhD or should we train them on the back end by extensive research training after medical work.

The truth is, there's no good answer. I always give three general reasons why it's good to do a combined program.

1) It's good to get a MD/PhD or DO/PhD because the training you get in both supplement whichever you end up doing. In other words, if you do clinical research or academics, your ability to appreciate and apply research to clinical practice is enhanced. Meanwhile, if you do research, your ability to understand disease to ask the right questions is enhanced.

That part doesn't really apply to you so much, but it's the general answer to the interview question 😉

2) By starting out on a physician-scientist training program (MSTP, MD/PhD, DO/PhD, etc), you get training more appropriate to that pathway in theory, rather than just doing a PhD and a MD alone. Good combined degree programs have this in mind and integrate in various ways the MD and the PhD so you begin thinking early about how they contribute to one another and produce new niches.

3) $$$. We won't delude ourselves and pretend this isn't important. The fellowship pathway will contribute at most $70,000 towards your debt (2 years x $35,000/year) in NIH grant money. That's not welcome news for someone who has greater than $200,000 in medical school debt. MD/PhD programs are usually (though not always!) fully-funded, which means you are paid a stipend throughout the entire program. That being said, I am yet to hear of a fully-funded DO/PhD program. I hear anecdotes where people have been offered a full package or have found their own funding, but no DO/PhD gives full funding to their students (and most don't give ANY medical school funding).

To me this means, you have to be darn sure you want to do the physician-scientist job somewhere down the line if you aren't even getting the money to help you with debt relief. In fact, your debt is going to increase as your loans accrue interest! In essence, (Emphasis here: this is all my opinion!!!) I would only enter a fully funded program for this reason. These not fully-funded programs tend not to be well integrated, so you get a MD and a PhD but without integration there goes reason #2 as well.

That being said, it is rare that fellows enter primarily research positions. The hurdles to doing so are growing. Besides the increasing debt load, the number of MD/PhDs is increasing. Many are beginning to look at it as if "The MD is a clinician only", and it will take some work to overcome that. That being said, you can always pick up the PhD as a fellow if you really want one. For basic science research, whether you want a PhD or not you're looking at on the order of 5 years of training. For clinical research, the training time, hurdles, and competition tends not to be so bad. At least for now. The funding for basic science research is extremely tight and you have alot of competition from PhDs.

There is a practical aspect as well to the fellow v. MD/PhD pathway that the pre-med should consider. Being a pre-med, medical student, and resident all suck. You put in long hours, get lots of abuse, and you are full of uncertainty about your future. You spend all your time doing someone else's bidding, having no idea where are you going to end up for your next stage, but constantly fighting to get there. When you finally become an attending yourself, you get a certain amount of autonomy and pay that whether you've been looking for it or not, is going to feel good when you're 30+ years old and probably have a family. Are you really going to want to go back and spend 5 years in a fellowship getting training on barebones pay only to fight to find a new job that will take more hours and pay you less than the job could have right then? This seduces alot of MD/PhDs out of the research pathway. It's worse for MDs, because their hurdles to getting a research job are even higher.

One thing I haven't really mentioned yet is that these programs are usually geared towards producing basic scientists only. The common argument is that you don't need a PhD to do clinical research. You might find a program that will let you do an epidemiology or social science PhD, but this is rare.

In summary, the problem looking up at this whole process as a pre-med is that you really don't know how your future is going to pan out. Some of us are very committed to a basic science pathway, and that's why we do the MD/PhD. That being said, a great number of us (more than half IMO, but you can't get stats on this) will fall off the path for the reasons I mentioned before. So, I always recommend that if you're not at least at this point in your life committed to doing basic science, just go to med school and figure it out later. The PhD is never a waste, but if your destiny is truly to become a clinician it will keep you from that for another 4 or so years--time that you could be working towards your early retirement.

Hope that's helpful. Feel free to IM me. That goes for any of you. I used to get a lot more random IMs and I enjoy those conversations :laugh:

Good luck,
Eric
 
I'll offer an opinion from someone getting a PhD to do clinical research. I'll try not to contradict Neuronix too much (although I'm sure we've said opposing things in the past on this topic :laugh: )

You certainly can do clinical research without a PhD, just as one can do basic research without an advanced degree. But, there are aspects of advanced training in biostatistics and epidemiology that will drastically improve the quality of your investigations. The purpose of any PhD is to train you ask the appropriate questions, and then figure out the best way to support and refute those hypothesis through experimental or clinical study design. Sure, we use different methods, and SDN has had a lot of threads talking about how neither is "better", whether you are thinking about it as "harder", more "rigorous", more "important", etc. The simple fact is that we need both, and we need people with expertise in their chosen field of study. And part of the phd is allowing you to mature as an investigator while being mentored by senior faculty. We all have to learn about grant writing, developing proposals and protocols, formulating hypotheses, and conducting research using appropriate methods.

There are options for doing clinical research without an advanced degree. With good mentoring, collaborative resources, and self-determination, you can produce adequate and publishable clinical research. There are also year long fellowships (Doris Duke and CDC, among others) for medical students to become immersed in clinical research. Also, a master's goes farther in clinical research than it does in basic science. According to my colleagues, a master's in basic science is sometimes viewed as the consolation price for those whose work couldn't turn into their dissertation research. But, a master's (either MS or MPH) in epi, biostats, or clinical investigation can provide you with a number of skills to do higher quality clinical research. A plus for that route is that you could do combined MD/master's programs, or you could have your master's paid for during some residency or fellowship programs. A downside is that, if not paid for, you're forking out the money for 2 professional degrees.

There are relatively few academic physicians with a PhD and who focus on clinical research, and the ones I know have great publications and funding records. I have no data to support this, but people keep telling me that I'll be a highly sought commodity, and their feeling is that PhDs in clinical research are probably more likely to stay in research (whether academics, government supported, or industry). Additionally, the opportunities to collaborate with basic science researchers should be plentiful, and funding is often more likely for projects that can show direct clinical relevance.

Even within clinical research, you have a very broad scope of opportunities. I'm more of a number cruncher, so I work with statistics, database management, large clinical trials, etc, to answer my questions. But if you still like lab work, there are physiologic studies, imaging, pathology & diagnosis, biomechanics, genetic epi, pharmacology, and infectious disease opportunities within the realm of clinical research. At the other extreme, there are people who focus on economic or behavioral aspects to medical care, which is also in high demand.

I certainly agree with the remainder of Neuronix's points - it's helpful to find out early on whether a dual degree fits your personal career path. Money and time are both important factors. The level of expertise you want will contribute to your decision as well, in addition to where you see yourself in the end (do you want to practice AND research? or use your exposure to one to improve your favorite?). There might be a slight advantage to having an MD even if you just want to do clinical research full-time - the MD opens up a lot of opportunities that aren't always available to straight PhDs.
 
I'll offer an opinion from someone getting a PhD to do clinical research. I'll try not to contradict Neuronix too much (although I'm sure we've said opposing things in the past on this topic :laugh: )

I don't think there's any contradiction between what we're saying. The point is still true that there are very few MD/PhD and DO/PhD students in the social sciences right now. Few MD/PhD programs will even let you do it with their full funding. Though, I imagine the programs that are poorly integrated and don't fund you, that sort of view you as just taking time off from med school for a PhD, won't mind. Never did I mean to say a PhD wouldn't benefit you in clinical research (in fact, I think I said the opposite).

The nice thing about clinical research is that you can usually pick up a master's or MPH along the way, and we agree that those degrees go alot further for clinical research than for basic science. So again I think the op's best course would be to start off in med school and figure out what is wanted later, unless she really has committed already to clinical research or basic science research. Remember too mushy, typically one needs 2+ years of research in clinical or bench research to apply to their respective programs. i.e. You'd want 2+ years of clinical research experience to apply for a MD/PhD in Epi, but that experience probably won't count if you apply for a MD/PhD in cell biology. I took a year off from ugrad and did bench research almost for the sole purpose of getting into a good MD/PhD program. You want to think to yourself if you're willing to put in that sort of commitment before starting med school.
 
In summary, the problem looking up at this whole process as a pre-med is that you really don't know how your future is going to pan out. Some of us are very committed to a basic science pathway, and that's why we do the MD/PhD. That being said, a great number of us (more than half IMO, but you can't get stats on this) will fall off the path for the reasons I mentioned before. So, I always recommend that if you're not at least at this point in your life committed to doing basic science, just go to med school and figure it out later. The PhD is never a waste, but if your destiny is truly to become a clinician it will keep you from that for another 4 or so years--time that you could be working towards your early retirement.
This applies to me pretty well. I'm going the other way, though -- I've been thinking about research for a while, but now I'm considering medicine. Do you think I should just apply to med school, then? The stipend is appealing, and basically one of the biggest reasons I was considering an MSTP... graduate with no debt, and I think there'd really be nothing like a PhD to convince me whether or not to keep doing research. I'm still strongly considering a PhD program alone, though. Any ideas?
 
This applies to me pretty well. I'm going the other way, though -- I've been thinking about research for a while, but now I'm considering medicine. Do you think I should just apply to med school, then? The stipend is appealing, and basically one of the biggest reasons I was considering an MSTP... graduate with no debt, and I think there'd really be nothing like a PhD to convince me whether or not to keep doing research. I'm still strongly considering a PhD program alone, though. Any ideas?

I know this argument has been made many times before, but I just wanted to point out that the MSTP actually is not a financially intelligent decision for those who intend to practice medicine only. At a private med school the student is saving the 50K tuition plus receiving a 25K stipend. Over 7-8yrs, all told the pecuniary benefit is somewhere on the order of 300-400K. But the 3-4yrs of extra education chop 3-4yrs off of the physician's career, meaning that the opportunity cost is 3-4yrs of the physician's income near retirement. Even when you factor in interest on the debt, virtually any physician save the most poorly paid academics earn more in the last 3-4yrs of their career. Really the only way the MSTP benefits you financially is if you otherwise couldn't receive a loan to pay for med school, but I have never heard of med students not qualifying for loans.

On the other hand, I can understand why some people wish to avoid going into debt. But to me, the 3-4 extra yrs of training that I didn't need or want, and the resultant unhappiness (the life of a poor grad student), would outweigh my disinclination to take on massive debt.

It's just my opinion that life decisions of this magnitude should be made irregardless of financial considerations. Anyone with our level of education will be able to scrape together a living under the worst of circumstances, and the more important issue should be whether we are pursuing a career that will make us happy in the long term.
 
For the record, I'm an aspiring MD/PhD in Clinical Research, and so my direct input is limited - but I'll give it anyways. I currently do clinical research at a teaching hospital and have not come across a single PI that I work closely with, who has a MD/PhD (granted I've been here for 1 year). The closest is a very young, very bright, very focused PI who has an MD/MS in Clinical Effectiveness (something like Clinical Investigation). The rest of the people I work with around the hospital are all straight MDs. Even the basic lab Director here is a straight MD. I should also note that my boss is an exceptional researcher and has had no formal training.

That being said, I will confirm what Neuronix and dante201 say - ultimately there are some major gains from understanding the theory and language of both domains. What is being trained is your ability to approach/frame/communicate/carry-out the investigation of challenging medical questions. Interestingly, I did some graduate work in Medical Informatics and a parallel can be made. Who's the better informatician? a trained computer scientist? or an MD who is good with data/computers? I believe this is an apples-to-orange comparison. Both have unique skills and thought-processes to bring to the table, but what is critical is bridging the two disciplines - that's precisely how I see the MSTP contributing. One would suspect that having the breadth and rigor of both basic and clinical training would allow an MSTP to investigate a number of questions that an MD or PhD may not as deftly frame, set-up, and execute on.

By the way, I give a hearty thumbs up 👍 👍 to all the posters. I'm continuously amazed at the insight here. Y'all are doing a bang-up job, and helping us Prospectives get a realistic peak at the next decade of our lives.
 
Hello:

I am PGY 3 resident in psychiatry and my program offered me the opportunity of a PhD in Neuroscience.
I am unsure if a PhD might be beneficial in the long run to be able to do research. I will be loosing money (46,000 vs 80-150,000 once I graduate per/year) 6 years is a lot of time and it will be nice to get different opinions in the subject.
 
I am unsure if a PhD might be beneficial in the long run to be able to do research. I will be loosing money (46,000 vs 80-150,000 once I graduate per/year) 6 years is a lot of time and it will be nice to get different opinions in the subject.

What you need to do is think long and hard whether you want a career doing 80%+ basic science (i.e. bench) research. Talk to other MDs and MD/PhDs that are just out of residency doing research and see what they think about their lives. That's what the PhD will help you do, set up a Neuroscience laboratory and write grants to support it.

If you think you might want to do anything else, I don't think it's going to be worth the time investment for you. Do a fellowship in something of interest and just take it from there.
 
Hello mushy, hope all is well.



We're all newbies. Don't worry about it.



This is always a difficult question that gets much debate on all levels. Which is the best way to train somebody to be a physician-scientist? Should we invest in them on the front end by giving them a PhD or should we train them on the back end by extensive research training after medical work.

The truth is, there's no good answer. I always give three general reasons why it's good to do a combined program.

1) It's good to get a MD/PhD or DO/PhD because the training you get in both supplement whichever you end up doing. In other words, if you do clinical research or academics, your ability to appreciate and apply research to clinical practice is enhanced. Meanwhile, if you do research, your ability to understand disease to ask the right questions is enhanced.

That part doesn't really apply to you so much, but it's the general answer to the interview question 😉

2) By starting out on a physician-scientist training program (MSTP, MD/PhD, DO/PhD, etc), you get training more appropriate to that pathway in theory, rather than just doing a PhD and a MD alone. Good combined degree programs have this in mind and integrate in various ways the MD and the PhD so you begin thinking early about how they contribute to one another and produce new niches.

3) $$$. We won't delude ourselves and pretend this isn't important. The fellowship pathway will contribute at most $70,000 towards your debt (2 years x $35,000/year) in NIH grant money. That's not welcome news for someone who has greater than $200,000 in medical school debt. MD/PhD programs are usually (though not always!) fully-funded, which means you are paid a stipend throughout the entire program. That being said, I am yet to hear of a fully-funded DO/PhD program. I hear anecdotes where people have been offered a full package or have found their own funding, but no DO/PhD gives full funding to their students (and most don't give ANY medical school funding).

To me this means, you have to be darn sure you want to do the physician-scientist job somewhere down the line if you aren't even getting the money to help you with debt relief. In fact, your debt is going to increase as your loans accrue interest! In essence, (Emphasis here: this is all my opinion!!!) I would only enter a fully funded program for this reason. These not fully-funded programs tend not to be well integrated, so you get a MD and a PhD but without integration there goes reason #2 as well.

That being said, it is rare that fellows enter primarily research positions. The hurdles to doing so are growing. Besides the increasing debt load, the number of MD/PhDs is increasing. Many are beginning to look at it as if "The MD is a clinician only", and it will take some work to overcome that. That being said, you can always pick up the PhD as a fellow if you really want one. For basic science research, whether you want a PhD or not you're looking at on the order of 5 years of training. For clinical research, the training time, hurdles, and competition tends not to be so bad. At least for now. The funding for basic science research is extremely tight and you have alot of competition from PhDs.

There is a practical aspect as well to the fellow v. MD/PhD pathway that the pre-med should consider. Being a pre-med, medical student, and resident all suck. You put in long hours, get lots of abuse, and you are full of uncertainty about your future. You spend all your time doing someone else's bidding, having no idea where are you going to end up for your next stage, but constantly fighting to get there. When you finally become an attending yourself, you get a certain amount of autonomy and pay that whether you've been looking for it or not, is going to feel good when you're 30+ years old and probably have a family. Are you really going to want to go back and spend 5 years in a fellowship getting training on barebones pay only to fight to find a new job that will take more hours and pay you less than the job could have right then? This seduces alot of MD/PhDs out of the research pathway. It's worse for MDs, because their hurdles to getting a research job are even higher.

One thing I haven't really mentioned yet is that these programs are usually geared towards producing basic scientists only. The common argument is that you don't need a PhD to do clinical research. You might find a program that will let you do an epidemiology or social science PhD, but this is rare.

In summary, the problem looking up at this whole process as a pre-med is that you really don't know how your future is going to pan out. Some of us are very committed to a basic science pathway, and that's why we do the MD/PhD. That being said, a great number of us (more than half IMO, but you can't get stats on this) will fall off the path for the reasons I mentioned before. So, I always recommend that if you're not at least at this point in your life committed to doing basic science, just go to med school and figure it out later. The PhD is never a waste, but if your destiny is truly to become a clinician it will keep you from that for another 4 or so years--time that you could be working towards your early retirement.

Hope that's helpful. Feel free to IM me. That goes for any of you. I used to get a lot more random IMs and I enjoy those conversations :laugh:

Good luck,
Eric


We should all buy Neuronix a dinner. :laugh: I'm a little late for the discussion, but thanks a lot for your help. That was a great read.
 
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