Medulloblastoma
Started by seper
However one has to point out, that there's another study out there showing bad results with reduced dose CSI + chemo:
http://www.ncbi.nlm.nih.gov/pubmed/7623725?dopt=Abstract
The Packer-trial results are impressive and have led to this therapy scheme becoming today's treatment standard, but it's still unclear, why other study groups have failed to reproduce these results.
Retrospective reviewers have suggested, that the study population included in Packer's-trial were very favorable "standard" risk medulloblastoma patients and that the problem with the European trial was giving chemotherapy first and radiation therapy later on, leading to radioresistant/repopulating tumor cells.
This is of course all theory, but I would keep these aspects in mind.
http://www.ncbi.nlm.nih.gov/pubmed/7623725?dopt=Abstract
The Packer-trial results are impressive and have led to this therapy scheme becoming today's treatment standard, but it's still unclear, why other study groups have failed to reproduce these results.
Retrospective reviewers have suggested, that the study population included in Packer's-trial were very favorable "standard" risk medulloblastoma patients and that the problem with the European trial was giving chemotherapy first and radiation therapy later on, leading to radioresistant/repopulating tumor cells.
This is of course all theory, but I would keep these aspects in mind.
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