- Joined
- Oct 6, 2016
- Messages
- 5
- Reaction score
- 1
Hey, sorry if this sounds like a really stupid question but I thought this would be the ideal place to ask this question for clarification. So uptodate seems to say for mild to moderate Alzheimer's Disease (MMSE < 26) a trial of cholinesterase inhibitors should be initiated and memantine is only added on if it is moderate-advanced Alzheimer's (MMSE < 17). However, I was looking at some sources that claimed that Memantine might potentially be disease-modifying. If that is the case, would it not be reasonable to start someone off with a trial of memantine instead of a cholinesterase inhibitor? What is the reason we don't start someone off with memantine first? Memantine's side effect profile does not look concerning at all. Are they both equally efficacious in improving cognition?