Step I memantine

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ctizzle13498

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10+ Year Member
Can someone explain this drug's MOA. I don't get how being an NMDA receptor blocker is linked to treating AD.

Thanks!
 
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ctizzle13498 said:
Can someone explain this drug's MOA. I don't get how being an NMDA receptor blocker is linked to treating AD.

Thanks!
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Alzheimers is characterized by glutamate neurotoxicity. NMDA is a glutamate receptor and is overactive, which may cause the neuronal damage, or be part of it. It is theorized that this toxicity is from prolonged Ca influx.

Memantine helps to block this.
 
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