C ctizzle13498 Full Member 10+ Year Member Oct 25, 2011 #1 Advertisement - Members don't see this ad Can someone explain this drug's MOA. I don't get how being an NMDA receptor blocker is linked to treating AD. Thanks!
Advertisement - Members don't see this ad Can someone explain this drug's MOA. I don't get how being an NMDA receptor blocker is linked to treating AD. Thanks!
1 123165 Oct 25, 2011 #2 ctizzle13498 said: Can someone explain this drug's MOA. I don't get how being an NMDA receptor blocker is linked to treating AD. Thanks! Click to expand... Alzheimers is characterized by glutamate neurotoxicity. NMDA is a glutamate receptor and is overactive, which may cause the neuronal damage, or be part of it. It is theorized that this toxicity is from prolonged Ca influx. Memantine helps to block this. Upvote 0 Downvote
ctizzle13498 said: Can someone explain this drug's MOA. I don't get how being an NMDA receptor blocker is linked to treating AD. Thanks! Click to expand... Alzheimers is characterized by glutamate neurotoxicity. NMDA is a glutamate receptor and is overactive, which may cause the neuronal damage, or be part of it. It is theorized that this toxicity is from prolonged Ca influx. Memantine helps to block this.
