MHC and NK cells for syncytiotrophoblast

[MudPhud20XX]

Firecracker was asking:

What hormone does the syncytiotrophoblast secrete and why does it not evoke an immune response?

Syncytiotrophoblast is the outer layer of the placenta

• Secretes hCG and lacks major histocompatibility complex antigens → doesn’t invoke an immune response

My question is won't NK cell still attack syncytiotrophoblast since it doesn't have MHC? Also, does hCG play a role in getting away with the immune response?

Many thanks!

---

Members don't see this ad.

 

[sanj238]

Firecracker was asking:

What hormone does the syncytiotrophoblast secrete and why does it not evoke an immune response?

Syncytiotrophoblast is the outer layer of the placenta

• Secretes hCG and lacks major histocompatibility complex antigens → doesn’t invoke an immune response

My question is won't NK cell still attack syncytiotrophoblast since it doesn't have MHC? Also, does hCG play a role in getting away with the immune response?

Many thanks!

NK cells are the innate immunity. Not humoral. They only attack external stuff cancer, viruses etc. They cant recognize self cells. If theres no MHC and theres nothing about it that says hey im an evil external thing then NK shouldnt attack them. I havent read anything about immunity and hcg so i dont think so

First of all, hcg is a hormone and all hormones are features of proteins....because they are proteins they most likely wont be associated with MHC because MHC is associated with CELLS. This should make sense since the epitopes that are presented to T and B cells are from proteins which make up hormones (along with fat and other stuff but they are NOT cells) that hcg doesnt have MHC is like saying cholesterol doesnt have MHC and thats why the immune system wont attack it. NO the immune system wont attack it because it only attacks cells. That proteins are involved in immune response is because the proteins of the insult are digested and presneted to a variety of immune mediators that then act ont his.

Firecracker is ******ed for posting that garbage. Shame on them

Edit, after looking online it seems like there are protiens on hcg that CAN elicit T cell response. so stupid of firecracker.

 

[ulikedaggers]

NK cells are the innate immunity. Not humoral. They only attack external stuff cancer, viruses etc. They cant recognize self cells. If theres no MHC and theres nothing about it that says hey im an evil external thing then NK shouldnt attack them. I havent read anything about immunity and hcg so i dont think so

First of all, hcg is a hormone and all hormones are features of proteins....because they are proteins they most likely wont be associated with MHC because MHC is associated with CELLS. This should make sense since the epitopes that are presented to T and B cells are from proteins which make up hormones (along with fat and other stuff but they are NOT cells) that hcg doesnt have MHC is like saying cholesterol doesnt have MHC and thats why the immune system wont attack it. NO the immune system wont attack it because it only attacks cells. That proteins are involved in immune response is because the proteins of the insult are digested and presneted to a variety of immune mediators that then act ont his.

Firecracker is ******ed for posting that garbage. Shame on them

Edit, after looking online it seems like there are protiens on hcg that CAN elicit T cell response. so stupid of firecracker.

NK cells do attack self-cells if the level of MHC1 expressed is reduced (e.g. cancer cells). This is why OP is asking why NK cells don't attack the syncytiotrophoblast (that lack MHC1 altogether). The answer lies in the fact that maternal antibodies prevent NK cells from binding to the syncytiotrophoblast. I don't know the details of that antibody or how it works, but that's what happens.

Lack of MHC1 makes syncytiotrophoblast "immune" to destruction by CD8 T cells. Lack of MHC1 also makes syncytiotrophoblasts susceptible to attack by NK cells, but maternal antibodies prevent NK cells from binding to the syncytiotrophoblast.

 

[sanj238]

NK cells do attack self-cells if the level of MHC1 expressed is reduced (e.g. cancer cells). This is why OP is asking why NK cells don't attack the syncytiotrophoblast (that lack MHC1 altogether). The answer lies in the fact that maternal antibodies prevent NK cells from binding to the syncytiotrophoblast. I don't know the details of that antibody or how it works, but that's what happens.

Lack of MHC1 makes syncytiotrophoblast "immune" to destruction by CD8 T cells. Lack of MHC1 also makes syncytiotrophoblasts susceptible to attack by NK cells, but maternal antibodies prevent NK cells from binding to the syncytiotrophoblast.

my bad...misread the q....though even after rereading it seems to ask about bhcg. Though thats not whats intended..

 

[sanj238]

NK cells do attack self-cells if the level of MHC1 expressed is reduced (e.g. cancer cells). This is why OP is asking why NK cells don't attack the syncytiotrophoblast (that lack MHC1 altogether). The answer lies in the fact that maternal antibodies prevent NK cells from binding to the syncytiotrophoblast. I don't know the details of that antibody or how it works, but that's what happens.

Lack of MHC1 makes syncytiotrophoblast "immune" to destruction by CD8 T cells. Lack of MHC1 also makes syncytiotrophoblasts susceptible to attack by NK cells, but maternal antibodies prevent NK cells from binding to the syncytiotrophoblast.

my bad i misread q.

interesting so this is a lot like allografts