Step I Micro resistance q

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msbbc833

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15+ Year Member
Hey yall,

I came across a question that asked about staphylococcus' mechanism of resistance to penicillin. I picked that it was due to presence of an enzyme (B-lactamase) that degrades it. Another choice was altered PBPs; but I thought that confers resistance to methicillin, naficillin, dicloxacillin. Is that correct?
 
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msbbc833 said:
Hey yall,

I came across a question that asked about staphylococcus' mechanism of resistance to penicillin. I picked that it was due to presence of an enzyme (B-lactamase) that degrades it. Another choice was altered PBPs; but I thought that confers resistance to methicillin, naficillin, dicloxacillin. Is that correct?
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For Staph it's the PBP alteration. Methicillin and the others are technically PCNs. I think your B-lactamases are restricted to your Gram negatives and is found in their periplasmic space.
 
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mastamark said:
For Staph it's the PBP alteration. Methicillin and the others are technically PCNs. I think your B-lactamases are restricted to your Gram negatives and is found in their periplasmic space.
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Yes that's true.

Another issue at hand is GPs just shoot beta lactamases into the open space surrounding them, but that's hardly as efficient.

Source: I think it was a question from the USMLEasy questionbank. Can't recall. But it was from one of the qbanks
 
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