Step I Microvilli dysfunction - qBank spoiler

[exmike]

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There was a qbank question where they asked in a mutation of which would cause dysfunction of microvilli (brush border) causing them to slough off.
The choices were desmin,desmoplakin, kinesin, dynein, and myosin.

The correct answer was myosin?!?, and only 17% of qbank takers got it right. (distributed randomly, you'd expect at least 20% if it was random guessing).

Sure, none of the other ones made sense either, but...

This is seriously a new one for me. Did you guys learn in histology that myosin was important for the integrity of microvilli?

 

[lord_jeebus]

I did learn in cell bio, either in med school or in undergrad (can't remember which) that actin was a major part of microvilli structure. Based on that, myosin seemed like the best guess.

Wikipedia's article on microvilli says it's true.

 

[exmike]

I did learn in cell bio, either in med school or in undergrad (can't remember which) that actin was a major part of microvilli structure. Based on that, myosin seemed like the best guess.

Wikipedia's article on microvilli says it's true.

yeah i got the actin/myosin thing.. i just never learned in histology that myosin was required for microvillus integrity.

 

[DOCTORSAIB]

HY Histo says actin also. Based on that, I probably would have picked myosin.

I haven't come across that question yet on Qbank. Guess I'll be part of that lucky 17% when I do...

My favorite one was the association of CYSTIC HYGROMA with Turner's! WTF!!!

 

[velo]

Don't stress too much about that, you have to understand how Kaplan writes questions. To give questions that seem like real test questions, but don't violate copyright, they use the "same but different" method of re-writing real step 1 questions. Meaning they test the same concepts as the real question, make you go through the same thinking as the real question, but change it so its different from the real question.

I bet dollars to donuts that the question that was based on, on a real USMLE, had microvilli dysfunction and the right answer was actin. Kaplan rewrote it thinking, "where there's actin, there's myosin."

chill, is aight.