MOA of Ranolazine

[TheNsg300]

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If Ranolazine works by blocking the late Na+ (slow) current, how is it that it results in the prolongation of AP and risk complication of torsades? I would think blockade of the late Na+ current would result in the shortening of the AP, similar to the effects of Class Ib Anti-arrhythmics. Ur inputs are highly appreciated!!

 

[stop2stop]

Has overlapping properties of inhibiting outward K channels. Source below. hope this helps.

http://eurheartjsupp.oxfordjournals.org/content/ehjsupp/6/suppl_I/i9.full.pdf