People normally rip the binding and stick it in a 3-ring binder in order to add pages/notes accordingly. I personally hate that idea, so I only annotate from UW, everything else I just read from the direct source.
However, the very thought of annotating DURING your first 2 years of medical school is giving me palpitations. You will already be on an extreme time crunch that finding an extra 5-6 hours during the week would be better spent hanging out/sleeping etc. But I guess to each their own.
Typically most people start around January of the year they will be taking the test in. That way you have the freshest FA. I would try and get an old FA from a friend, just to read along class, and then buy the new one come step 1 time.