mural thrombi

[lilmisty]

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Does anyone know why mural thrombi form in the walls of enlarged atria (ie, enlarged LA from mitral stenosis)? I can't find the answer anywhere and its bugging me. It doesn't seem to make sense...?!

Also, bonus question, but does anyone know why mitral valve leaflets "fuse" sometimes in rheumatic disease? I don't get that either.

>_< Aghhhhh I'm super frustrated and flustered right now 🙁

 

[Matteo]

Does anyone know why mural thrombi form in the walls of enlarged atria (ie, enlarged LA from mitral stenosis)? I can't find the answer anywhere and its bugging me. It doesn't seem to make sense...?!

Also, bonus question, but does anyone know why mitral valve leaflets "fuse" sometimes in rheumatic disease? I don't get that either.

>_< Aghhhhh I'm super frustrated and flustered right now 🙁

My understanding is that it's was due to hemostasis considering the LA is now dilated.

 

[lilmisty]

Wouldn't that just form regular thrombi? Or does it form both, you think?

 

[thehundredthone]

What do you mean by regular thrombi? The haemostasis also means that the thrombus doesn't really get propelled out, and so it grows along the wall, forming a "mural" thrombus.

 

[CherryRedDracul]

My understanding is that it's was due to hemostasis considering the LA is now dilated.

This. Hemostasis is part of the classic Virchow's triad for thrombus formation.

Wouldn't that just form regular thrombi? Or does it form both, you think?

Mural thrombus just means that they form on endothelial walls ("mural" means "relating to a wall"). Mural thrombi occur in the heart or on large vessel walls and are not occlusive, but only reduce blood flow, if anything. Occlusive thrombi, on the other hand, form in small vessels and can cause ischemia.

If a mural thrombus gets dislodged, let's say from atrial fibrillation, then this free-floating mass of coagulated stuff is called an embolus.