my big fat second messenger and receptor mechanism cheat sheet

[doctorFred]

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UPDATE: peter90036 gave it a slick new interface and i updated it to add the janus kinase pathway; it should now be complete. i also took out the pictures to make it smaller, and it now fits in a PDF (see attached below.)

original post
after hearing about how high yield the second messengers and receptor mechanisms were for step 1 for the millionth time (and realizing that i had no idea how atrial natriuretic peptide actually works), i decided to put together this little "cheat sheet." i basically went through first aid, goljan, kaplan biochem, wikipedia and usmleworld, and wrote out the mechanism for the receptor activation of basically every ligand in the body you need to know for step 1 (i could NOT, for the life of me, find one simple, free, comprehensive source for this information; some of them are presented in such a convoluted way.)

it should be an easy read and a good reference. everything is written out so that a 10 year old (me) can understand it. ligands are highlighted in green, second messengers are highlighted in red, and i even drew pretty pictures.

in case any other people were in my shoes, i'm attaching it to this message as a word file. if it helps anyone, great.

 

[peter90036]

nice, can you save as "Word document 97-2003" , not sure people have the latest office,
or maybe as PDF

 

[anon-y-mouse]

Where are the pictures?! j/k, it's actually pretty good 🙂 You're absolutely right though, no book makes this clear at all... except for the cult classic 1999 HY CMB (very last chapter), and even that doesn't go as far as making enough links -- I had to combine that info with Uworld questions for a fuller picture.

I would further make the distinction between receptor tyrosine kinases (autophosphorylate -- ras/raf/mapK): all the growth factors and insulin, and tyrosine kinase-associated receptors (phosphorylates something else... I believe this is janus kinase / jak/stat): growth hormone, prolactin, IL-2, and cytokine receptors if I remember correctly. I also remembered that receptor tyrosine phosphatase was CD45 associated (over-expressed in lymphomas), and receptor serine-threonine kinase was TGF-beta associated.

also vaguely remember that I had to know a couple of motifs and what they bound (Zn finger: DNA obvi, the amino acid composition of a couple of other motifs).

This is all going off memory, so you might want to look it up to confirm before you take my word on it!

 

[doctorFred]

edit: see updated first post

 

[doctorFred]

edit: see updated first post.

 

[doctorFred]

and just for fun.. here's what the pictures looked like before i yanked them:

 

[car123]

Thanks!

 

[wcec]

Great job, zahque! Thank you for sharing. 👍 i couldn't open the picture file, i'd be interested in taking a look at that.

 

[Joe Louis]

Thank you Z

 

[yunan]

thanks Zahque. That'll really help out! cheers

 

[doctorjoy]

THis is great!!!!

 

[Proverbs31]

Thanks sooo much for sharing! Cant see the pics but great outline!

 

[symphony]

Thank you so much. This file has helped me 🙂

 

[JG198]

Well done

 

[Panoramix]

Thank u! Excellent work! 👍

 

[ZonaRidicularis]

.

 

[vsmedic]

How thoughtful! Thanks to both of you. Goodluck for the steps.

 

[spoon]

Soooo helpful, I was planning on making one (and dreading it). Thank you!

 

[34140]

thanks i grabbed it

 

[InspireMe]

Thanks a bunch, it looks really good

 

[medstudent11]

Thanks for putting this together! I'm trying to collect sheets like this to study from, and like you said, it's difficult to find sources that present material like this concisely. When along the timeframe of studying for Step 1 do you think it's best to break study sheets like this out? I suppose all along and then again the last week before the test to refresh yourself?

~Medstudent11
http://themedstudentexperience.blogspot.com

 

[Oreoomar]

I think i might love you

 

[hopeinternist]

THANKS for bumping this thread!