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65 yr old man undergoes operation to remove an abd mass,histological examination shows,large number of blood vessels,further analysis shows increased VEGF in tumor, which of the following stimulated the production of vegf in the tumor?
increased endostatin
decreased endostatin
increased pco2
decreased pco2
increased po2
decreased po2
increased thrombospondin
decreased thrombospondin
I feel like multiple choices can be answers here.. Obviously decreased pO2 causes increased VEGF via same mechanism in macular degeneration of high altitude acclimatization, but why can't "decreased endostatin" or "decreased thrombospondin" be answer as well?
Endostatin and thrombospondin are both VEGF inhibitors, sometimes expressed in tumors to produce angiogenic effect.
Thanks in advance.
increased endostatin
decreased endostatin
increased pco2
decreased pco2
increased po2
decreased po2
increased thrombospondin
decreased thrombospondin
I feel like multiple choices can be answers here.. Obviously decreased pO2 causes increased VEGF via same mechanism in macular degeneration of high altitude acclimatization, but why can't "decreased endostatin" or "decreased thrombospondin" be answer as well?
Endostatin and thrombospondin are both VEGF inhibitors, sometimes expressed in tumors to produce angiogenic effect.
Thanks in advance.