.This thread is lovely, thank you.
I have a few more questions.
The CREST syndrome question involving esophageal motility. Was the answer decreased LES and peristalsis? I was thinking CREST and achalasia were friends so I had the LES tone arrow up.
They are friends in the sense that you lose esophageal peristalsis in both, but CREST leads to lower sphincter tone (-> GERD) and achalasia leads to higher sphincter tone (-> bird beak)
Can anyone further explain why the answer to this was "homing": The question about mice melanoma that spreads everywhere, until you inject an antibody in the liver that protects the liver from the mets. I went with invasion. Fail.
Invasion = invasion through basement membrane. The antibody selectively prevents targeting to the liver (i.e. homing)
There was the young girl who clearly had albinism-like characteristics, neutropenia, but recurrent bacterial infections. I went with decreased NADPH oxidase but that was incorrect. I must be missing some association on this one...
Don't remember the question exactly, but sounds like Chediak-Higashi to me
Kid with either Becker/Duchenne had weak adduction, and weakness of an additional muscle that attaches where? Answer was previously listed as ischium. But I am terrible at anatomy from having a hardcore orthopod prodigy attack my cadaver (and not paying attention, clearly). Which muscle are they talking about? Thanks. I am terrible at anatomy.
I believe it's gluteus maximus
Gentamicin/aminoglycoside toxicity at the tubules. I went with collecting tubule. Was proximal correct?
In general, nephrotoxins target the PCT selectively in ATN
Doctor was trying to give a drug for cough suppression that would not cause constipation or addiction. I ended up going with tramodol because all of the others seemed addicting. Anyone know the correct answer for this one?
Trucker sitting in car for 10 hours goes through with a V/Q scan. I am assuming he had a PE. I went with Decreased ventilation with normal perfusion. This was wrong.
Embolus blocks pulmonary artery -> decreased perfusion of that portion of the lung.. ventilation is intact
Any help would be great. I apologize for not posting the answer choices. UWorld has me conditioned not to try and print screen or copy anything.
Also, has anyone that has taken Step 1 have any advice on the most predictive test? I was scoring 240s on UWorld Assessments, the 150Q free practice test, and DIT's end of course exam. But my NBME scores these last couple days have been 230ish. Not a good sign close to exam day.
Thanks and good luck to all.