NBME #4 Error?

[Quixotic]

---

Members don't see this ad.

Is this question a mistake? I thought you are supposed to treat with T4 because it has a longer half life.

T3 is more potent that T4 in treating hypothyroidism because of which of the following:

1)active transport into target cell
2)greater accumulation in the mitochondria
3)greater receptor affinity
4)higher oral bioavailability
5)longer plasma half life



Also, for those who have taken the exam, which of the 4 forms is most representative of the real thing?

 

[nrosigh]

The answer is 3.

T4 enters the cell, where it is converted to T3 in the cytoplasm. T3 then travels to the nucleus where it can interact with its receptor. T3 has a higher affinity for the receptor than does T4.

You're right, that T4 has a longer half life: T3 is degraded pretty quickly.

Let me know if you have any more questions...

Is this question a mistake? I thought you are supposed to treat with T4 because it has a longer half life.

T3 is more potent that T4 in treating hypothyroidism because of which of the following:

1)active transport into target cell
2)greater accumulation in the mitochondria
3)greater receptor affinity
4)higher oral bioavailability
5)longer plasma half life



Also, for those who have taken the exam, which of the 4 forms is most representative of the real thing?

 

[hale-bopp]

Also, for those who have taken the exam, which of the 4 forms is most representative of the real thing?

overall, most like form 2. but the biochem/immuno part of the test was most like 3 or 4.