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There are a few NBME 4 threads but none of them discuss overarching content.
I encountered a few difficulties:
Octreotide versus somatostatin. How does the former differ from the endogenous substance pharmacologically?
Decreased lipid solubility
Decreased volume of distribution
Delayed onset of action
Prolonged duration of action
Increased bioavailability
A young woman has skin blistering from a single point mutation in a single gene. What is the effect of the genetic mutation?
Defective transport of vesicles
Disrupted keratin assembly into intermediate filaments
Lack of GTP to form polymers of tubulin
Phosphorylation of actin monomers to promote polymerization
A woman comes to you with depression and alcoholism and says, doc my husband abuses me physically and emotionally.
Do you say..
Do you feel safe at home?
Battering just gets worse over time. For the sake of your safety and self-esteem, you should end this relationship.
Frankly I felt that either one is acceptable as an initial response. Is there some rule that physicians should not tell patients to get out of relationships? If they are being abused by report but have psychiatric disorders, what is the protocol.
First-pass metabolism of carcinogens like cigarette smoke involves:
Conjugation with glutathione
Glycosylation by glycosyl transferases
Oxidation by cytochrome P450
Oxidation by mitochondrial cytochrome A
Sulfation by sulfotransferases
These are estimations of the concepts of the questions, not directly copied content.
I encountered a few difficulties:
Octreotide versus somatostatin. How does the former differ from the endogenous substance pharmacologically?
Decreased lipid solubility
Decreased volume of distribution
Delayed onset of action
Prolonged duration of action
Increased bioavailability
A young woman has skin blistering from a single point mutation in a single gene. What is the effect of the genetic mutation?
Defective transport of vesicles
Disrupted keratin assembly into intermediate filaments
Lack of GTP to form polymers of tubulin
Phosphorylation of actin monomers to promote polymerization
A woman comes to you with depression and alcoholism and says, doc my husband abuses me physically and emotionally.
Do you say..
Do you feel safe at home?
Battering just gets worse over time. For the sake of your safety and self-esteem, you should end this relationship.
Frankly I felt that either one is acceptable as an initial response. Is there some rule that physicians should not tell patients to get out of relationships? If they are being abused by report but have psychiatric disorders, what is the protocol.
First-pass metabolism of carcinogens like cigarette smoke involves:
Conjugation with glutathione
Glycosylation by glycosyl transferases
Oxidation by cytochrome P450
Oxidation by mitochondrial cytochrome A
Sulfation by sulfotransferases
These are estimations of the concepts of the questions, not directly copied content.