Need help finding info about Phenidone

[pinkyrx]

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Hi everybody!

I am in the process of doing a patient assessment for a clerkship experience and am having trouble finding information about the drug, Phenidone. My patient has DM, Hep B and epilepsy if that helps at all.

Have any of you heard of it? I've tried looking it up via various searches and can only find instances where it is used in photo processing and not as a medication. (edited to add: I did find one case where it was used in a study of DM/arteriosclerosis)

I keep thinking maybe I spelled it incorrectly, but I don't think that is the case.

If anyone has any info about it or could point me towards a good resource I would certainly appreciate it.

Thanks!

 

[Caverject]

Hi everybody!

I am in the process of doing a patient assessment for a clerkship experience and am having trouble finding information about the drug, Phenidone. My patient has DM, Hep B and epilepsy if that helps at all.

Have any of you heard of it? I've tried looking it up via various searches and can only find instances where it is used in photo processing and not as a medication. (edited to add: I did find one case where it was used in a study of DM/arteriosclerosis)

I keep thinking maybe I spelled it incorrectly, but I don't think that is the case.

If anyone has any info about it or could point me towards a good resource I would certainly appreciate it.

Thanks!

Are you sure it's not Phenobarb? Phenobarb is used for seizures.... I just looked in my 1st edition Goodman & Gillman (printed in 1941) and came up with Phenazone but that is an antipyrine. You may very well have it misspelled if you have not worked with drugs before your first clerkship.

 

[pinkyrx]

Are you sure it's not Phenobarb? Phenobarb is used for seizures.... I just looked in my 1st edition Goodman & Gillman (printed in 1941) and came up with Phenazone but that is an antipyrine. You may very well have it misspelled if you have not worked with drugs before your first clerkship.

Well, I suppose anything is possible... I'm rather "OCD" about checking spellings and doses before I leave the hospital, so I am pretty sure the spelling is not that far off if it is off at all.

I did find a drug called phenindione. It's a coumadin derivative, but from everything I read about it, it's no longer administered in the US because of potentially fatal side effects.

Our preceptor has a tendency to give us unique cases, so I'm wondering if perhaps this drug is perhaps the "unique" part of this case.

I am probably way overthinking this... but is there any chance that she could be part of some study or something testing out this drug?

I found mention of it on page 2 of this article in reference to DM:
http://www.findarticles.com/p/articles/mi_m0922/is_n9_v43/ai_15828602/pg_1

 

[Sosumi]

It sounds more like phenytoin to me. That's also used for tonic clonic seizures.

 

[pinkyrx]

It sounds more like phenytoin to me. That's also used for tonic clonic seizures.

The patient is taking phenytoin as well as this "phenidone" drug.

 

[pinkyrx]

I found this: (not sure if it will help anyone help me or not, but I thought I'd post it anyway)

"phenidone is an inhibitor of the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism”

 

[jemc2000]

I found this: (not sure if it will help anyone help me or not, but I thought I'd post it anyway)

"phenidone is an inhibitor of the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism”

Yeah, this is what I found at link

Previous studies from our laboratory indicated that the lipoxygenase inhibitor phenidone markedly attenuates angiotensin II (AII) induced vascular contractility. Phenidone was also shown to inhibit the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat. We have now examined the effects of phenidone in the spontaneously hypertensive rat (SHR).

 

[Caverject]

Can you post the actual case?

 

[pinkyrx]

Can you post the actual case?

Here is some more info about the patient:

Main complaint N/V/D X2 days, hypoglycemic upon admission.

Seizure disorder, Diabetes Mellitus, left sided hemiparesis due to stroke, chronic Hepatitis B. She has a family history of diabetes.

Current Meds:
Levetiracetam (Keppra) 500mg BID
Clonazepam (Klonopin) 0.5mg TID
Promethazine (Phenergan) PRN
Hydrocodone/APAP 5/500mg (Vicodin) Q4hrs PRN
Multivitamin
Phenidone 100mg BID
Glyburide (Micronase) BID (dose unclear)
Fexofenadine + P-Ephed (Allegra D)60/120mg BID
Fludrocortisone (Florinef) 0.1mg QAM
Phenytoin (Dilantin) SR 100mg BID
Ondansetron injection PRN

 

[pinkyrx]

Notice how phenytoin and phenidone are the same dose/schedule? I'm beginning to think that someone typed the name phenidone when they heard "phenytoin", which was perhaps said incorrectly.

I will find out officially tomorrow, so I'll let you guys know. As for now, I'm going to leave it in my report since I am sure that it was listed in the chart as a current medication.

Thanks for all the help!

 

[ZpackSux]

Notice how phenytoin and phenidone are the same dose/schedule? I'm beginning to think that someone typed the name phenidone when they heard "phenytoin", which was perhaps said incorrectly.

I will find out officially tomorrow, so I'll let you guys know. As for now, I'm going to leave it in my report since I am sure that it was listed in the chart as a current medication.

Thanks for all the help!

Could it be Primidone?

 

[Caverject]

Another anti-convulsant? Makes sense....

 

[pinkyrx]

Notice how phenytoin and phenidone are the same dose/schedule? I'm beginning to think that someone typed the name phenidone when they heard "phenytoin", which was perhaps said incorrectly.

I will find out officially tomorrow, so I'll let you guys know. As for now, I'm going to leave it in my report since I am sure that it was listed in the chart as a current medication.

Thanks for all the help!

Thanks again for all the help! Turns out I was right about the transcriber hearing the word incorrectly. They recorded it as phenidone when it should have been phenytoin!

Seems that everyone else knew that, but being that I'm a lowly P1 I just assumed it was a real drug.

 

[tupac_don]

Here is some more info about the patient:

Main complaint N/V/D X2 days, hypoglycemic upon admission.

Seizure disorder, Diabetes Mellitus, left sided hemiparesis due to stroke, chronic Hepatitis B. She has a family history of diabetes.

Current Meds:
Levetiracetam (Keppra) 500mg BID
Clonazepam (Klonopin) 0.5mg TID
Promethazine (Phenergan) PRN
Hydrocodone/APAP 5/500mg (Vicodin) Q4hrs PRN
Multivitamin
Phenidone 100mg BID
Glyburide (Micronase) BID (dose unclear)
Fexofenadine + P-Ephed (Allegra D)60/120mg BID
Fludrocortisone (Florinef) 0.1mg QAM
Phenytoin (Dilantin) SR 100mg BID
Ondansetron injection PRN

Okay now you are thinking of primidone, not phenidone. Primidone is used for seizures, its a phenobarbital derivative or metabolite or something or other. It is also used for tremor. It makes no sense that they would use this drug "phenidone" even if it does exist. You are dealing with primidone, and the dose you gave is correct for primidone.

 

[pinkyrx]

Okay now you are thinking of primidone, not phenidone. Primidone is used for seizures, its a phenobarbital derivative or metabolite or something or other. It is also used for tremor. It makes no sense that they would use this drug "phenidone" even if it does exist. You are dealing with primidone, and the dose you gave is correct for primidone.

Nope, actually it was phenytoin that they were referring to. The spot that I saw phenidone written in the chart was from when the patient was initially admitted and told them what her home meds were. There was a communication breakdown between the patient and the person taking the info and the person that typed up the report that I read. Not sure where they mistake occurred, but I verified with the doctor today that it was indeed an error and it should have said phenytoin.

 

[VCU07]

What are the patients liver function tests like? Patient is on Hydrocodone/APAP 5/500. Also, no Aspirin? Patient does have history of stroke and DM. Im sure there are other things, but I've got a test tom. So, good luck!

Here is some more info about the patient:

Main complaint N/V/D X2 days, hypoglycemic upon admission.

Seizure disorder, Diabetes Mellitus, left sided hemiparesis due to stroke, chronic Hepatitis B. She has a family history of diabetes.

Current Meds:
Levetiracetam (Keppra) 500mg BID
Clonazepam (Klonopin) 0.5mg TID
Promethazine (Phenergan) PRN
Hydrocodone/APAP 5/500mg (Vicodin) Q4hrs PRN
Multivitamin
Phenidone 100mg BID
Glyburide (Micronase) BID (dose unclear)
Fexofenadine + P-Ephed (Allegra D)60/120mg BID
Fludrocortisone (Florinef) 0.1mg QAM
Phenytoin (Dilantin) SR 100mg BID
Ondansetron injection PRN

 

[ZpackSux]

What are the patients liver function tests like? Patient is on Hydrocodone/APAP 5/500. Also, no Aspirin? Patient does have history of stroke and DM. Im sure there are other things, but I've got a test tom. So, good luck!

Well, pt has Hep B... but not being treated for it. Either patient is a carrier and has not not developed hepatitis yet... since I don't see Hep B treatment or it's quite possible that patient will have elevated enzymes in LFT... and will soon be a candidate for a treatment.