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- Aug 11, 2007
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Hey,
Could somebody please give me a hand. I have conducted an experiment on the rate of dissolution of aspirin in different dosage forms. I had some significant findings with the Cartia Duentric (enteric) coated aspirin tablet,
there was signs of discolouring in the pH 7 and 8.4 phosphate buffered solution made of KH2PO4 and NaOH. Does anyone know what causes this discolouring?
Also, when the enteric aspirin tablet was placed in the pH 7 phosphate buffered solution, the pH increases to 7.1 while it is decolourising. This is within the time frame of 15-20 mins. After 24 hrs, the enteric tablet cracked and aspirin is exposed to the solution however, the pH is 7.4 which increased by 0.4. Does anyone know the cause of this?
The temperature remained constant at 20 deg C (room temperature).
Thanks for your help...
Could somebody please give me a hand. I have conducted an experiment on the rate of dissolution of aspirin in different dosage forms. I had some significant findings with the Cartia Duentric (enteric) coated aspirin tablet,
there was signs of discolouring in the pH 7 and 8.4 phosphate buffered solution made of KH2PO4 and NaOH. Does anyone know what causes this discolouring?
Also, when the enteric aspirin tablet was placed in the pH 7 phosphate buffered solution, the pH increases to 7.1 while it is decolourising. This is within the time frame of 15-20 mins. After 24 hrs, the enteric tablet cracked and aspirin is exposed to the solution however, the pH is 7.4 which increased by 0.4. Does anyone know the cause of this?
The temperature remained constant at 20 deg C (room temperature).
Thanks for your help...