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This table in the FA 2015 says that nitrates have no effect on contractility, yet they increase heart rate via the baroreceptor reflex. Doesn't the reflex also increase contractility, though?
I think they are talking about DIRECT effect.This table in the FA 2015 says that nitrates have no effect on contractility, yet they increase heart rate via the baroreceptor reflex. Doesn't the reflex also increase contractility, though?
View attachment 188942
I think they are talking about DIRECT effect.
That's why they specified that it is a reflex response and not a direct action.But then why is the increase in HR shown as a reflex response?
That's why they specified that it is a reflex response and not a direct action.
I think what the take home message for us is that nitrates mainly causes reflex tachycardia and although it also causes +ve inotropy via sympathetic stimulation it is not as significant as reflex tachycardia.I guess I was just thinking it would've made more sense for them to show both as either direct or reflex responses, and not direct for one and reflex for the other. Oh well. Thanks though.
I guess I was just thinking it would've made more sense for them to show both as either direct or reflex responses, and not direct for one and reflex for the other. Oh well. Thanks though.
Also I just did a question in Rx that references this table (for beta blockers) and the correct answer reflects what FA2014 says, NOT what FA2015 says. I reported it, but we'll see what happens.
QBanks are always behind ...........unless they messed up the arrows 2015.Also I just did a question in Rx that references this table (for beta blockers) and the correct answer reflects what FA2014 says, NOT what FA2015 says. I reported it, but we'll see what happens.
QBanks are always behind ...........unless they messed up the arrows 2015.