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Have you guys in hospital seen this? What do you think of it?
I've gone through pubmed, uptodate, e-therapeutics, lexi, product monograph -> found absolutely no evidence to support use greater than 24 hrs continuously.
Tolerance is demonstrated to develop through 3 mechanisms, the first cases interestingly being demonstrated through bomb makers who used to work on nitroglycerin found they'd get headaches and feel lightheaded after working with it - but after a couple of days they'd feel fine.
I've gone through pubmed, uptodate, e-therapeutics, lexi, product monograph -> found absolutely no evidence to support use greater than 24 hrs continuously.
Tolerance is demonstrated to develop through 3 mechanisms, the first cases interestingly being demonstrated through bomb makers who used to work on nitroglycerin found they'd get headaches and feel lightheaded after working with it - but after a couple of days they'd feel fine.