NMDA and Cell Death?

[Kluver_Bucy]

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Does anyone know the mechanism of this relationship? I can't find this information anywhere. Thanks in advance. 👍

K

 

[Ramoray]

If your talking like ischemia induced neuronal injury nmda it is caused by upregulation of NMDA receptors on ischemically injured cells which allow Ca flow through and too mcuh Calcium due to upregulating too many receptor floods the cytoplasm with calcium which activiates all sorts of endnucleases, proteases, and free radicals which damage the membrane and causes cell death as well as increasing membrane permeabliity of the mitochondria which releases caspases, which activates apotosis.

 

[Idiopathic]

This is correct, it is all about excess calcium inflow, usually stimulated by excessive glutamate release and activation of the NMDA receptor (excess neuronal excitation)

 

[Kluver_Bucy]

Thanks for the help guys. Ramoray, you are right I meant NMDA receptors.