MD NSAIDs and acute renal failure

[aysenur]

---

Members don't see this ad.

why we should take too much water while taking NSAIDs as painkillers(like voltarin,apranax)

 

[Merely]

Nsaids constrict blood vessel decreasing blow flow to kidney so drink water to increase blood flow

 

[aysenur]

Nsaids constrict blood vessel decreasing blow flow to kidney so drink water to increase blood flow

Thank u for answer. I thought if we use nsaids, we end up with decreased GFR and increased blood volume, so if we already have increased blood volume why its necessary to take water

 

[sliceofbread136]

Thank u for answer. I thought if we use nsaids, we end up with decreased GFR and increased blood volume, so if we already have increased blood volume why its necessary to take water

Prostaglandins act to vasodilator kidney vasculature in response to decreased flow, mostly secondary to decreased volume. With nsaids you lose this compensatory mechanism and are much more susceptible to pretense aki

 

[arcus]

You are correct OP.

“Nephrotoxicity, reported for all NSAIDs, is due, in part, to interference with the autoregulation of renal blood flow, which is modulated by prostaglandins”

“Diclofenac, 150 mg/d, appears to impair renal blood flow and glomerular filtration rate. Elevation of serum ami-notransferases occurs more commonly with this drug than with other NSAIDs.”
- Katzung Pharmacology text, chapter on NSAIDS