1. Dismiss Notice
  2. Download free Tapatalk for iPhone or Tapatalk for Android for your phone and follow the SDN forums with push notifications.
    Dismiss Notice
Dismiss Notice
Visit Interview Feedback to view and submit interview information.

Ochem help- Robinson Annulation

Discussion in 'Pre-Pharmacy' started by jmcfa002, Jun 2, 2008.

  1. jmcfa002

    jmcfa002 UCSF SoP c/o 2014
    2+ Year Member

    Joined:
    Oct 16, 2007
    Messages:
    423
    Likes Received:
    0
    Status:
    Pre-Pharmacy
    I'm in my second quarter of ochem, and I'm studying the "robinson annulation"

    I'm having a hard time with it, does anyone have a good way of explaining it?

    Thanks
     
  2. Note: SDN Members do not see this ad.

  3. OrllY

    OrllY Awesome
    2+ Year Member

    Joined:
    Jan 29, 2008
    Messages:
    69
    Likes Received:
    1
    Status:
    Pharmacy Student
    Michael + Aldol.
    just look for those acidic hydrogens and see what you can do with them.
     
  4. AbsoluteEthanol

    AbsoluteEthanol PHARMACY STUD
    2+ Year Member

    Joined:
    Jan 15, 2008
    Messages:
    331
    Likes Received:
    1
    Status:
    Pharmacy Student

    couldn't have said it better myself! occam's razor at its finest here!

    p.s. i could never understand why people ask chemistry/biology questions on SDN. Is this seriously your main resource when you have a problem you cannot solve? i should hope not!
     
  5. jmcfa002

    jmcfa002 UCSF SoP c/o 2014
    2+ Year Member

    Joined:
    Oct 16, 2007
    Messages:
    423
    Likes Received:
    0
    Status:
    Pre-Pharmacy
    No, its not my main source. I studied it for about 20 minutes today and couldn't figure it out, and I'm going to school tomorrow to get help. I've been studying it and trying to figure it out better before I go to ask for help. I was thinking that someone may have an easy way to do it.

    I don't know Michael's addition, so maybe that is the problem.
     
  6. ExpressMaiL

    ExpressMaiL alea iacta est
    Pharmacist 10+ Year Member

    Joined:
    Oct 26, 2007
    Messages:
    1,101
    Likes Received:
    234
    Status:
    Academic Administration
    The annulation is a great reaction.
     
  7. OrllY

    OrllY Awesome
    2+ Year Member

    Joined:
    Jan 29, 2008
    Messages:
    69
    Likes Received:
    1
    Status:
    Pharmacy Student
    i may have written a paper on this...
     
    #6 OrllY, Jun 2, 2008
    Last edited: Jun 8, 2008
  8. Sparda29

    Sparda29 En Taro Adun
    Pharmacist Classifieds Approved 10+ Year Member

    Joined:
    Mar 25, 2008
    Messages:
    8,856
    Likes Received:
    807
    Status:
    Pharmacist
    Are you serious? Just download BitComet, and then go to PirateBay and download any cracked version of office.
     
  9. jmcfa002

    jmcfa002 UCSF SoP c/o 2014
    2+ Year Member

    Joined:
    Oct 16, 2007
    Messages:
    423
    Likes Received:
    0
    Status:
    Pre-Pharmacy
    or use open office, it can do .doc
     
  10. rycetrix

    7+ Year Member

    Joined:
    May 12, 2008
    Messages:
    395
    Likes Received:
    0
    Status:
    Resident [Any Field]

    Robinson Annulation...I just taught my students how to do this so yea..(I am a tutor)

    So here we go:

    It is as some people have stated above, it is a Michael followed by an aldol. A Michael addition is basically an enolate + an alpha, beta-unsaturated carbonyl. The enolate adds to the double bond of the alpha, beta-unsaturated carbonyl. The product of Michael reaction is a 1,5-dicarbonyl compound. The aldol part is basically the Michael product undergoes an intramolecular attack. This is performed by making an enolate on part of the Michael product, and then it will attack the other carbonyl since this is a dicarbonyl compound (2 carbonyls). And then the molecule will undergo aldol condensation to get the desired product, which should have an alpha, beta-unsaturated carbonyl in it. And that would be the Robinson Annulation product.

    It is quite hard to describe the reactions without actually showing you what is going on.

    Let me know if this helps.
     

Share This Page