My
LizzyM is 75 so i'm competitive-ish stats-wise for Stanford and Penn (a little bit on the low end, but close enough to their medians). This includes two C+s in my freshman year however (including one in Gen Bio), although that (thankfully) acted as enough of a wake-up call that I was able to drag my GPA kicking and screaming to where it is over the next 3 years.
I was not realistically expecting IIs at Penn, Stanford, and Mayo with very late secondaries since stats-wise I would have been very borderline even if my apps were early. If I were to speculate wildly, I feel for Stanford at least my research experience may have sold them enough to want to check me out in person (I was a CompSci and Neurobio double major, and worked on CS-centric cross-disciplinary medical research over all four years of my degree, including with a few publications). All my other ECs are very middle of the road (almost nothing outside of volunteering and some shadowing, and neither doing anything exciting, although with decent hours). I'm also ORM (Asian).
Part of the reason I left both my Stanford and Mayo applications until October was because my pre-health advisor at my undergrad institution had been adamant that even thinking of applying to those schools with my application (and particularly the two C+s) would be a "waste of time". Given that my only IIs have been from these schools, I definitely can't say that I regret taking the advice of some folks on SDN, ignoring my school's pre-health office, and applying anyway though
🙂.