Official Step 1 HY Microbio Concepts & Discussion Thread

[Mr. Mojo Risin]

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Feel free to use this thread to discuss HY Micro concepts. Good luck to everyone!

Links to the other HY subject threads:

Biochemistry: http://forums.studentdoctor.net/thr...y-biochem-concepts-discussion-thread.1115421/

Cardiology: http://forums.studentdoctor.net/thr...ardiology-concepts-discussion-thread.1115425/

Endocrinology: http://forums.studentdoctor.net/thr...crinology-concepts-discussion-thread.1115426/

Gastroenterology: http://forums.studentdoctor.net/thr...nterology-concepts-discussion-thread.1115427/

Hematology/Oncology: http://forums.studentdoctor.net/thr...-oncology-concepts-discussion-thread.1115428/

Immunology: http://forums.studentdoctor.net/thr...mmunology-concepts-discussion-thread.1115423/

MSK/Skin/Connective Tissue: http://forums.studentdoctor.net/thr...ve-tissue-concepts-discussion-thread.1115430/

Neurology: http://forums.studentdoctor.net/thr...neurology-concepts-discussion-thread.1115431/

Psychiatry: http://forums.studentdoctor.net/thr...sychiatry-concepts-discussion-thread.1115432/

Renal: http://forums.studentdoctor.net/threads/official-step-1-hy-renal-concepts-discussion-thread.1115433/

Reproductive: http://forums.studentdoctor.net/thr...roductive-concepts-discussion-thread.1115434/

Respiratory: http://forums.studentdoctor.net/thr...spiratory-concepts-discussion-thread.1115435/

 

[TOKOY90]

Wait, you're (accepted)? What on earth are you doing in this thread. Go enjoy your summer.

They also gave no physical exam findings associated with tetanus, which they love to do, and I've never heard of a tetanus infection being particularly associated with a foul smell. Immunizations can wane or be ignored, not a good rule out reason.

I have two more weeks until I am done with my master's, then i will definetely enjoy my summer.

Generally, all anaerobic infections may be described as having foul smell odor.

 

[theTruth_97]

Wait, you're (accepted)? What on earth are you doing in this thread. Go enjoy your summer.

They also gave no physical exam findings associated with tetanus, which they love to do, and I've never heard of a tetanus infection being particularly associated with a foul smell. Immunizations can wane or be ignored, not a good rule out reason.

 

[cs24]

 

[theTruth_97]

oh sorry idk but my post got messed up. yeah my ? was based off of a random school given NBME test that was given to us- im assuming I forgot to add a helpful detail or too, but i just feel like "foul odor + wound" is unique enough that it should give us an answer

If i find out what it is ill post it

 

[seminoma]

What microorganism comes to your mind if I give you a case of a guy falling off of his bike and develop a wound on his knee and that wound having a "foul smell"?

Perfringens

 

[seminoma]

I thought about perfringens too and that's a better response given the extent of immunization for tetanus

Even without immunization perfringens is higher on the differential. Tetani is unlikely to cause gas accumulation compared to perfringens. That's the whole reason why people don't seek treatment until they start having bad muscle cramps.

 

[theTruth_97]

A patient from India comes in with night sweats, hemoptysis, and a cough. Rather than treating the patient the physician is more interested in reading his first aid book about the virulence factors of this organism. What is the virulence factor that inhibits phagolysosome fusion? And name the other virulence factor along with its function as well.

 

[cs24]

oh sorry idk but my post got messed up. yeah my ? was based off of a random school given NBME test that was given to us- im assuming I forgot to add a helpful detail or too, but i just feel like "foul odor + wound" is unique enough that it should give us an answer

If i find out what it is ill post it

That was plenty of info. If you use sketchy micro (and if your micro is weak, you should), they also said that a motorcycle crash is the classic cause of a c. perfringens infection, so that one actually should have been a gimme if you knew that. Deep wound from crash --> perfringens until proven otherwise.

 

[cs24]

A patient from India comes in with night sweats, hemoptysis, and a cough. Rather than treating the patient the physician is more interested in reading his first aid book about the virulence factors of this organism. What is the virulence factor that inhibits phagolysosome fusion? And name the other virulence factor along with its function as well.

Sulfatides. Cord factor- activates macs and induces granuloma formation (although wiki says cord factor blocks phagolysosome fusion as well).

 

[theTruth_97]

That was plenty of info. If you use sketchy micro (and if your micro is weak, you should), they also said that a motorcycle crash is the classic cause of a c. perfringens infection, so that one actually should have been a gimme if you knew that. Deep wound from crash --> perfringens until proven otherwise.

see i even knew that (since i have started doing sketchy micro which I love) but when I was taking the test I was like "hmmm i don't recall a foul smell though- that must be a unique feature of something").....i need to learn to not overthink everything

 

[theTruth_97]

Sulfatides. Cord factor- activates macs and induces granuloma formation (although wiki says cord factor blocks phagolysosome fusion as well).

and yes bingo! that is correct- good job

 

[theTruth_97]

How exactly does Boutlism cause diplopia? (which is part of that diplopia, dysphonia, dysphagia triad right)

 

[Radiolucent]

How exactly does Boutlism cause diplopia? (which is part of that diplopia, dysphonia, dysphagia triad right)

As you know C. Botulinum toxin (Botox) decreases/blocks the release of ACh from presynaptic neurons --> flaccid paralysis. The extraocular muscles are also involved (as are laryngeal/pharyngeal muscles --> dysphonia/phagia) which leads to diplopia. As simple as that.

 

[theTruth_97]

Haha woww I don't know why I was overthinking it so much. Thanks a bunch!