You want two 4s in five attempts. There are (5 choose 2) = 5!/3!2! = 10 ways to select which two rolls of the five are 4s.
Answer = 10*(1/6)^2*(5/6)^3 = (10*125)/(36*216).
You get 10 from the (5 choose 2). You get (1/6)^2 because those are the two rolls that land on 4. You get (5/6)^3 because those are the three rolls that land on any of the other 5 numbers.