My BFF recently went to work for an independent (3 small stores in a big city) and their niche is compounding, and specifically bioidentical hormones.
Last month, I went on vacation in northern Wisconsin and stopped in at a small town independent; they had a contract with some dairy farms and other entities for veterinary compounding, and the pharmacy shared space with a store that sold collectible glass and local sports team t-shirts. When I told the owner, who looked to be about 70 years old, that I was a pharmacist (albeit not one that's licensed in Wisconsin) he opened the Dutch door and invited me to step back behind the counter and check it out. I'm pretty sure he was serious, and I did decline the invitation.