I am a resident of MI.
As far at the out of state tuition costs, they are high, yes. I have not met very many classmates who are from out of state. I know that they do purposely limit the number of out of staters in each class - since they are funded partially by the state of Michigan they must. However, the out of state tuition price doesn't make it that far off some of the private DO schools. Additionally, I have seen much worse out of state costs.
If you are from outside MI, tuition is one downside to MSUCOM, but I think it is worth applying and checking out the school when you interview, then making your decision.