I've heard of this book and just did a quick search on reviews for the book. I work in clinical research and took some coursework regarding new drug development at a pharmacy college. Some of the issues that were identified in the book are regulated by the FDA and are issues that drug companies have to take into consideration when designing trials. There are many people involved in running a trial and from what i've seen (i've worked in insutry a little over 3 years), if something is considered a little biased, most researchers (project managers, statisticians, data managers, regulatory, monitors, etc) will be more conservative in order to keep the results valid. Regarding pharmaceutical marketing and sales, I think patients/consumers really have to be careful about believing what is advertised (and this goes across the board in our society).