Pathology Question

[saburi]

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[perennialdent]

i think its 5

 

[DrTacoElf]

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[Swordfish]

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[Ramla Hameed]

its 3. hageman factor initiates formation of kallikrien,which causes release of bradikinin. kinins cause the long lasting effects of dilating small blood vessels, inducing a fall in blood presssure, triggering smooth muscle contraction, and increasing the permeability of vessel walls. In addition, activation of the coagulation pathway by hageman produces a vascular permeability factor.

 

[Ramla Hameed]

2, 4 and 5 will cause the same effects, but not for several days

 

[DrTacoElf]

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[Ramla Hameed]

i never said the answer is bradykinin dear. its hageman factor, which initiates formation of kallekrien from prekallekrien and also bradykinin release. all kinin like mediators cause these effects. u are right its not vascular dmage so it cant be 4 or 5

 

[DrTacoElf]

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[dentheartthrob]

Vasodilation and increased vasopermeability ,lasting for several days in an area of inflammation, indicate which of the following ?

1. Thrombosis
2. Histamine Release
3. Hageman Factor activation
4. Formation of granulation tissue.
5. Endothelial cell damage and disruption.

Please answer.

Thanks

i say 2, cause hageman factor activation is too broad per se. hageman factor when activated, in turn is able to activate three plasma systems involved in inflammation: the kinin system, fibrinolysis system, and coagulation system(wikipedia-inflammation) The last two of these systems are indicated on damage blood vessels, and under the content of the question I think 2 would be more specific.

 

[saburi]

thanks guys!!!