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PCOS and endmetrial adenocarcinoma

Discussion in 'Step I' started by MudPhud20XX, Aug 17, 2015.

  1. MudPhud20XX

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    A UW q I got makes the connection between PCOS and endometrial adenocarcinoma, but with no real explanation, can anyone help me out? Many thanks.
     
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  3. cs24

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    PCOS = high androgens (hence the symptoms). High circulating androgens are converted to estrone in the periphery which causes endometrial hyperplasia over time. Also PCOS = anovulatory bleeding. If you are not ovulating, you never have progesterone to balance out your estrogen = prolonged states of estrogen stimulation without counterbalance.
     
    Transposony, Keto and MudPhud20XX like this.

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