Step I PCOS and endmetrial adenocarcinoma

[MudPhud20XX]

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A UW q I got makes the connection between PCOS and endometrial adenocarcinoma, but with no real explanation, can anyone help me out? Many thanks.

 

[cs24]

PCOS = high androgens (hence the symptoms). High circulating androgens are converted to estrone in the periphery which causes endometrial hyperplasia over time. Also PCOS = anovulatory bleeding. If you are not ovulating, you never have progesterone to balance out your estrogen = prolonged states of estrogen stimulation without counterbalance.