MudPhud20XX

5+ Year Member
Nov 26, 2013
1,345
193
Status
Medical Student
A UW q I got makes the connection between PCOS and endometrial adenocarcinoma, but with no real explanation, can anyone help me out? Many thanks.
 
Mar 26, 2013
501
499
Status
Medical Student
PCOS = high androgens (hence the symptoms). High circulating androgens are converted to estrone in the periphery which causes endometrial hyperplasia over time. Also PCOS = anovulatory bleeding. If you are not ovulating, you never have progesterone to balance out your estrogen = prolonged states of estrogen stimulation without counterbalance.
 
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