I'm headed into Anesthesia and my personal statement was mentioned to me by several interviewers and PD's in Prelim Med, Transitional, and Anesthesia interviews. You'd be amazed.
As for a hook, I would try to make your personal statement as "personal" as possible, thus the name. Remember, you are trying to stand out (for the right reasons) in the interview process, so you may want to think of some things that make you somewhat unique and include those. Have you traveled to foreign places, invented something, started your own business, been in a car wreck, all of these types of situations would be "hooks." It all depends on how you integrate them into what you are trying to convey about yourself as to whether they will work or not. Each situation mentioned above has the potential to show off you, your growth, your experience, your personality, your dedication/perseverance, your uniqueness, why you chose a particular field, your breadth as a person within and beyond medicine, etc. Having said all that, there will likely be similarities between your personal statement and other people's personal statements who are entering into your field. For example, many people going into anesthesia go into the field for its hands-on nature and the immediate results obtained from one's work. If those reasons for entering the field are in a future anesthesiologist's personal statement they will suggest that the applicant "fits." So, be personal, but show why you fit into your chosen specialty.
As a side note, I hear that tons of people start with a "profound" quote. I read many of my friends' personal statements and, to me, that "hook" got old fast. I guess that others could say the same about my suggestions above as well, but at least the beginnings above would be directly about you. Just get your reader into the personal part about you and what you are trying to convey as quickly as you can.
As someone mentioned above, their personal statement may have gotten them an interview or two. I would keep that in mind and put some effort into your personal statement. You never know just what part of your application may make the difference for you, and the personal statement is one of those things over which YOU have control.