“There is nothing new to be discovered in physics now. All that remains is more and more precise measurement.” Lord Kelvin 1900
Interesting quote. While Kelvin was clearly wrong about physics, he was wrong because radical paradigm shifts were on the horizon (quantum mechanics and relativity). Regarding radonc, a radical paradigm shift would mean an intervention unlikely to be in our hands.
Adaptive MRI guided XRT, protons etc. are all attempts to improve conformality "
All that remains is more and more precise treatment.". As we've discussed before, reaching the zenith of conformality is unlikely to be a game changer in oncology.
In the short term, the high capital investment in initiatives to marginally improve conformality (and perhaps Grade 1-2 toxicity) do little more than create a rupture between docs at large institutions, who overwhelmingly train our field, and the the docs who tend to the societal need for radiation away from these large institutions. The large institutions have to date overstated the value of these interventions and marketed directly to patients to improve market share.
In the long term, most solid tumors are now largely viewed as systemic diseases, with the outcomes of interest (death and disability) largely driven by systemic progression. Our interventions (and improved conformality) are continuously contextualized to the systemic therapy of the moment and the systemic therapy is improving rapidly. We have seen what 20 years of evidence based medicine can do when supported by pharma and a string of new drugs. We have yet to see what will happen once AI driven drug design really starts impacting the upstream volume of drug candidates.
In the present, the medical oncology machine has probably prematurely bought into the "it's all systemic disease" mantra and diminishes the value of anatomically focused therapeutic interventions (see DLBCL) for their patients. As their drugs get better, they will eventually be more right.
Radonc does remind me of physics. In post atom bomb, post Sputnik, cold war era USA, there was a push for physics in terms of national security, renewable energy etc. It's where the really smart kids went. Good programs were available in many universities. Of course the jobs dried up and many really smart physicists minted in 70s going forward had to change fields. Some of them changed to biology (the power of molecular bio and genetics becoming much more apparent in the 70s) and have had remarkable academic careers.
It's a shame. Cause physics just so much prettier than bio IMO.