PFK activation??

[JavMD]

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According to Goljan- Hypoxemia results in respiratory alkalosis. And alkalosis activates PFK in order to compensate shifting OBC to the right.
But then I read in BRS that PFK is activated as a result of hypoxic cell injury.

So my question is, are these two completely different mechanisms?

Logically, ATP depletion would activate PFK, driving the metabolism into an anaerobic glycolisis state. But how does alkalosis activate PFK?

 

[agranulocytosis]

I thought that the main regulator for PFK-1 was PFK-2 being activated/inactivated via insulin and glucagon respectively.

 

[Blesbok]

According to Goljan- Hypoxemia results in respiratory alkalosis. And alkalosis activates PFK in order to compensate shifting OBC to the right.
But then I read in BRS that PFK is activated as a result of hypoxic cell injury.

So my question is, are these two completely different mechanisms?

Logically, ATP depletion would activate PFK, driving the metabolism into an anaerobic glycolisis state. But how does alkalosis activate PFK?

Increased PH causes a left shift of the OBC, so then PFK is activated in order to form more 2,3-DPG from 1,3-DPG in glycolysis to compensate and shift the curve back ot the right.

At the same time, the decrease in ATP causes an increase in glycolysis by activating PFK.

I have no clue, I am just talking out of my ***. 😳

 

[JavMD]

Agranulocytosis- check out cell injury in pathology. Even though levels of H, citrate and AMP are not the main regulators or activators or PFK, these are important to understand the pathophysiology.

Blesbok- you are right. I just thought there was more to it molecularly on the activation of PFK by alkalosis.

Thanks guys.

 

[agranulocytosis]

Ahh, I gotcha now, JavMD. I went and read that little blue box in Goljan and seems to me the only relevant information we would need to get out of this point is the equillibrium of the O2 dissociation curve. But as far as any allosteric activation or anything is concerned, I have no clue. Sorry I'm of no help. 🙁

 

[JavMD]

Thanks bro, don´t worry.
Sometimes I get obsessed with minutiae.
Very bad habit.

Good luck.