Step I RAAS' activation in nephrotic syndrome

[Ven0m]

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Man w/ nephrotic syndrome (and hence a puffy face) has urine low in Na+ and high in K+. Does anyone know if the low urine Na+ and high urine K+ are due to:

• Nephrotic syndrome --> decreased plasma oncotic pressure --> edema --> less circulating volume stimulates RAAS --> aldosterone increases Na reabsorption and K+ secretion --> low urine Na+ and high urine K+?

Or are these urine electrolytes due to something else going on?

 

[alprazoslam]

Man w/ nephrotic syndrome (and hence a puffy face) has urine low in Na+ and high in K+. Does anyone know if the low urine Na+ and high urine K+ are due to:

• Nephrotic syndrome --> decreased plasma oncotic pressure --> edema --> less circulating volume stimulates RAAS --> aldosterone increases Na reabsorption and K+ secretion --> low urine Na+ and high urine K+?

Or are these urine electrolytes due to something else going on?

For the sake of step 1 your reasoning is sufficient and enough correct

 

[Ven0m]

For the sake of step 1 your reasoning is sufficient and enough correct

Thanks it just keeps all the physiology and stuff straight in my head lol

 

[alprazoslam]

Step 1 doesn’t go any more in depth than that so u should be good. That would be in the harder end of questions if they gave you nephrotic syndrome and asked what urine lytes looked like