EXACTLY!
Organic Chemistry lab isn't analogous to working in a research lab ... AT ALL.
In Orgo lab, you have a set protocol that usually works. You know what you're synthesizing, you're in a controlled environment (aka a 4 hour lab) and you have all of the utensils that you need to perform your experiment.
Laboratory research is a completely different beast that I've rambled about frequently on SDN. You're typically given a project (not necessarily of your own choosing) and you're forced to become the expert on the topic. Literature searches are common and you're usually searching for something which is akin to finding a needle in a hay stack. Then, you have your advisor ... Your advisor may or may not be helpful, your graduation is dependent on your advisor since you don't have a set curricula that determines your graduation, etc. 4 years for a PhD so RARELY happens that I'm surprised that most people actually expect that as the norm. Most graduate programs have a rather poor retention rate (for American students vs. International Students due to the pesky visa requirement that is analogous to indentured servitude), depending on funding, etc.
Graduate school can be a positive experience, but at the school that I attended for my PhD, we had 3 out of 24 American PhD students actually finish the program without being Mastered out of the program or quitting because they weren't interested in working 60+ hours per week for approximately 20-25K/year. With respect to International students, their stay in the country was intrinsic on their advisor's pleasure or displeasure with their work, so I had a lab mate who was in the lab 75 hours/week, who sent her child back to China to stay with her grand parents since she wasn't able to take care of her due to her school schedule. (She was eventually Mastered out of the program after 4 years in the program.) This is part of the reason why I find those complaining about Pharmacy to be absolutely foolish ... Your program has a set schedule, you typically make 100K a year after graduation and yet, you complain about working with patients in retail. *smirk* Suck it!
Therefore, if an undergrad is actually interested in research, they should work in a lab prior to even thinking about starting the program. Of course, pursuing a PhD while in a PharmD program is a different beast, but I don't know HOW different the beast is, if it is different at all.