Phenylalanine and Tryptophan vs. Gastrin

[acciddropping]

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Do you guys know the reason why Phenylalanine and Tryptophan are potent stimulators of Gastrin?

 

[NeuroLAX]

I researched it because other than simply knowing this fact, I had no idea why/how.

Apparently it is not fully understood, but it could have something to do with a specific calcium receptor on G cells. Supposedly knocking out this CaR did not produce gastrin secretion despite phenylalanine at levels one might see following a meal.

If you want to read it for yourself, here's the link

 

[acciddropping]

I researched it because other than simply knowing this fact, I had no idea why/how.

Apparently it is not fully understood, but it could have something to do with a specific calcium receptor on G cells. Supposedly knocking out this CaR did not produce gastrin secretion despite phenylalanine at levels one might see following a meal.

If you want to read it for yourself, here's the link

OK txks - i would not have guessed them as stimulators because they are precursors for NE and Epi and G cells are under Vagal control. But, that's what it is, I guess.

 

[NeuroLAX]

OK txks - i would not have guessed them as stimulators because they are precursors for NE and Epi and G cells are under Vagal control. But, that's what it is, I guess.

Careful. True, G cells are under vagal control, but ACh does not stimulate gastrin secretion, that's the job of GRP.

 

[acciddropping]

Careful. True, G cells are under vagal control, but ACh does not stimulate gastrin secretion, that's the job of GRP.

You're right!