Physical Chemistry class

[futuredruggist]

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Does anybody have a Physical Chemistry (ie thermodynamics) requirement?

To those who are practicing, how do you use thermodynamics (enthalpy, entropy, Gibbs energy, etc.) in your work, if at all?

 

[Farmercyst]

Does anybody have a P-chem requirement?

To those who are practicing, how do you use thermodynamics (enthalpy, entropy, Gibbs energy, etc.) in your work, if at all?

USC SOP doesn't require it and so far there hasn't been a need for it. We haven't discussed enzyme kinetics and only mentioned lattice energies in passing when discussing the rate of solution in conjunction and crystal structure.

 

[pinkyrx]

Does anybody have a P-chem requirement?

To those who are practicing, how do you use thermodynamics (enthalpy, entropy, Gibbs energy, etc.) in your work, if at all?

I don't know of any schools that require P-Chem. I took the class and can say that I've never used the stuff I learned (or stumbled through) since.

 

[futuredruggist]

UCSF requires it in year 1. I'm taking it now.

 

[pharmacogenomic]

I've actually used some of that information in practice.

For example, an anesthesiologist doesn't get the response he/she expects & wants to have the vials sent back. This is not an unusual request nor an inexpensive one!

But, if you pursue the issue a bit more, get more detail on the circumstances of the injection - where it was given (what level), what it was mixed with, understand the kinetics & chemistries of each compartment (epidural, spinal, intrathecal) and how they equilibrate with the blood/liver. Then taking into account the other issues going on - pH of the blood, drugs inducing liver enzymes, renal function.....you can often explain why something didn't work as expected.

I'v also used it when having to compound a sterile product from non-sterile ingredients. For ophthalamics, I often use the Jules Stein Institute for a resource for many sterile ophthalamic products. But, sometimes, I have to come up with them on my own. If you understand the pharmaceutical chemistry behind what you're doing, your less likely to make a bad mistake.

 

[Jbuprepharm]

I took Pchem 1 in undergrad, but the prof was terrible and I learned nothing in my B

it was so poor that I switched to biology to avoid taking the second semester

 

[futuredruggist]

I've actually used some of that information in practice.

For example, an anesthesiologist doesn't get the response he/she expects & wants to have the vials sent back. This is not an unusual request nor an inexpensive one!

But, if you pursue the issue a bit more, get more detail on the circumstances of the injection - where it was given (what level), what it was mixed with, understand the kinetics & chemistries of each compartment (epidural, spinal, intrathecal) and how they equilibrate with the blood/liver. Then taking into account the other issues going on - pH of the blood, drugs inducing liver enzymes, renal function.....you can often explain why something didn't work as expected.

I'v also used it when having to compound a sterile product from non-sterile ingredients. For ophthalamics, I often use the Jules Stein Institute for a resource for many sterile ophthalamic products. But, sometimes, I have to come up with them on my own. If you understand the pharmaceutical chemistry behind what you're doing, your less likely to make a bad mistake.

If I understand right you are saying you have used kinetics and pharmaceutical chemistry. What about thermodynamics (ie intro physical chemistry)?

 

[sleazye]

If I understand right you are saying you have used kinetics and pharmaceutical chemistry. What about thermodynamics (ie intro physical chemistry)?

We are doing all that stuff in pharmaceutics. We already covered flux in relation to drug transport. Today we were integratrating rate equations and we do thermodynamics later this week.

 

[futuredruggist]

Interesting. We spend a quarter each on thermodynamics and kinetics. What school are you at?

 

[genesis09]

We cover a little bit of relevent P-Chem in Pharmaceutics. It was only a few lectures and labs.

 

[wbrown]

We also have a semester of p chem. We're doing all of the thermo stuff, kinetics, and just started acid/base chemistry. I'm at UT Austin.