There must have been a reason you wanted to go to DePaul (perhaps the gorgeous campus? haha...I'm about to move just a few blocks from there). Don't transfer before you even start...give DePaul a shot, because you picked that school for a reason.
Don't worry about what your major is...you'll quickly find out that you can major in whatever you want, and as long as you take the prereq classes you can still apply/get into PT school. There is no "pre-med" or "pre-PT" major...you could be a biology major, but if you don't love it don't do it. You also will have plenty of opportunities to take classes that meet those prerequisites, but aren't necessarily required for your major...you should be able to take them as elective courses, or for gen eds (I'm not totally sure how Depaul works, but I'm sure they have a minimum number of science/math/social sciences/English classes everyone has to take...just try to take classes that are required for PT school so you can kill 2 birds with 1 stone.)
I was a communications and dance major at Northwestern, and am about to start PT school there. I have a good friend who was a year ahead of me, majored in dance, and is now a med student at Rosalind Franklin...she completed the dance major, and then since you have to take a certain number of classes each term anyway, she took her bio/chem/orgo/physics classes in addition to her dance classes. I did the same thing once I decided PT was the route I wanted to go.
It's not necessary to major in exercise science or bio in order to go to PT school, and sometimes those oddball majors stand out to the admissions committee. Looking at our incoming class at NUPT, we have some exercise science and bio majors, of course, but we also have dance majors, psych majors, business, language and other random majors too...a few people are fresh out of undergrad, some have taken a year off to work (yours truly), and some have been in the working world for several years and decided to do PT instead. And no offense to the kineso/ex phys majors, but an entire class of exercise science majors would be extremely boring. The great thing about PT school is the variety of backgrounds you get, which lets everyone learn from each other and bring something different to the table.
Maybe accounting isn't the right major for you, so you can always be undecided. I literally changed my mind 8 or 9 times in college...I didn't decide to do PT until my senior year, so I spent a year after graduation taking all the science courses at local community colleges and through Northwestern's continuing studies program to get those extra classes in. You could also do that...since you're starting much earlier than I did, look into taking those prereq classes at community college during the summers.
You'll also benefit by being near a ton of great PT facilities...Children's Memorial is practically on your campus, so you can try to observe PTs there, or at one of the numerous outpatient ortho clinics. Get lots of observation experience - not only is it required for admission, but it'll give you a feel for the profession and can help you decide if it's definitely what you want to do.
Look into what is required for PT school admission at the schools you might be interested in...granted it's still 4 years away for you, but still. UIC, NU, and Rosalind Franklin are all within a close distance to DePaul, so you could talk to their admissions office or visit the schools. You'll realize that there are a few basic requirements for PT admission: a Bachelor's degree, GRE scores, PT observation, and those prerequisite classes. They don't care what your degree is in as long as you have one and meet the other requirements...that's why my friend and I chose dance. We knew we'd be spending a ton of time studying for our prereq classes, so we wanted to have fun when we weren't in those hard classes. Find something you love to do and major in that...but make sure it's something that you can find a job with in case you decide PT isn't what you want to do down the line. For me if I didn't do PT, I'd be doing some sort of non-profit dance/arts management, so my dance/communications degree wouldn't be totally useless. But, now that I'm going to PT school, I know I enjoyed my undergrad experience doing something I loved.
I hope this helps? Don't stress too much. You still have a long time to figure it out.
