Is this related to a specific MCAT scenario?
Anyway:
Frictional force is always opposing the relative motion of the body. When a body is dragged along a rough surface, the frictional force will be acting in the direction opposite to the displacement. The angle between the frictional force and the displacement of the body will be 180o. Thus, the work done by the frictional force will be negative.
Work done by a force is negative if the applied force has a component in a direction opposite to the displacement.