Plasma lyte A vs Normosol R 7.4

[BLADEMDA]

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These 2 fluids are almost identical. They both contain the same elements in them per MEQ.

So, why does the sodium acetate in mg per 100 mls of solution vary from one to the other? Anyone care to explain?

I am curious to find the answer. Any med students with a Chem major who can answer?

 

[BLADEMDA]

PLASMA-LYTE A Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) is a sterile, nonpyrogenic isotonic solution in a single dose container for intravenous administration. Each 100 mL contains 526 mg of Sodium Chloride, USP (NaCl); 502 mg of Sodium Gluconate (C6H11NaO7); 368 mg of Sodium Acetate Trihydrate, USP (C2H3NaO2•3H2O); 37 mg of Potassium Chloride, USP (KCl); and 30 mg of Magnesium Chloride, USP (MgCl2•6H2O). It contains no antimicrobial agents. The pH is adjusted with sodium hydroxide. The pH is 7.4 (6.5 to 8.0).

PLASMA-LYTE A Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) administered intravenously has value as a sousrce of water, electrolytes, and calories. One liter has an ionic concentration of 140 mEq sodium, 5 mEq potassium, 3 mEq magnesium, 98 mEq chloride, 27 mEq acetate, and 23 mEq gluconate. The osmolarity is 294 mOsmol/L (calc). Normal physiologic osmolarity range is 280 to 310 mOsmol/L. Administration of substantially hypertonic solutions may cause vein damage. The caloric content is 21 lcal/L.



Normosol®-R pH 7.4 is a sterile, nonpyrogenic, isotonic solution of balanced electrolytes in water for injection. The solution is administered by intravenous infusion for parenteral replacement of acute losses of extracellular fluid.

Each 100 mL of Normosol-R pH 7.4 contains sodium chloride, 526 mg; sodium acetate, 222 mg; sodium gluconate, 502 mg; potassium chloride, 37 mg; magnesium chloride, hexahydrate 30 mg. May contain hydrochloric acid and/or sodium hydroxide for pH adjustment. pH range 6.5 to 7.6; 295 mOsmol/liter (calc.).

Electrolytes per 1000 mL (not including pH adjustment): Sodium 140 mEq; potassium 5 mEq; magnesium 3 mEq; chloride 98 mEq; acetate 27 mEq; gluconate 23 mEq.

 

[BLADEMDA]

Is it the type of sodium acetate being used?


Normosol R 7.4

Sodium Acetate, USP is chemically designated sodium acetate, anhydrous (C2H3NaO2), a hygroscopic powder soluble in water. It has the following structural formula:


The chemical formula for the sodium acetate in Normosol R seems to be the same as the Plasmalyte A yet the Mg per 100 mls of each is different. Yet, the MEQ per 1,000 mls is the same.

 

[lord_jeebus]

Sodium acetate trihydrate is C2H9NaO5, sodium acetate is CH3COONa, so the former has three extra oxygen atoms and 6 extra hydrogen atoms per molecule. That should explain why Plasma-Lyte has more mg for the same mEq, but I'm too lazy to do the math to show it.

 

[narcusprince]

Blade one thing missing is whats the definition of a miliequilivent? And whats the charge of the anions of each? This is where the answer lies as to why you have a balanced solution with both yet more mg of one over the other.

 

[BLADEMDA]

Blade one thing missing is whats the definition of a miliequilivent? And whats the charge of the anions of each? This is where the answer lies as to why you have a balanced solution with both yet more mg of one over the other.

Thanks.


http://www.healthline.com/natstanda...nt-and-millimole-calculations-and-conversions


Scroll down to the bottom. the different molecular composition and weights of the sodium acetate determine milliequivalents.

 

[BLADEMDA]

Sodium acetate trihydrate is C2H9NaO5, sodium acetate is CH3COONa, so the former has three extra oxygen atoms and 6 extra hydrogen atoms per molecule. That should explain why Plasma-Lyte has more mg for the same mEq, but I'm too lazy to do the math to show it.

Correct. Thank You